J. Chu

Signal transduction pathways controlling Ins2 gene activity and β cell state transitions

The paper identifies Ins2 gene activity states in beta cells and shows that cAMP activators drive transitions between these states.

Mannose Supplementation Curbs Liver Steatosis and Fibrosis in Murine MASH by Inhibiting Fructose Metabolism

This study shows that mannose reduces liver steatosis and fibrosis in MASH by inhibiting fructose metabolism, offering a potential therapeutic approach.

Forsythoside A blocks the infection of Avian Infectious Bronchitis Virus through binding S1 subunit

This study shows Forsythoside A inhibits Avian Infectious Bronchitis Virus by binding to its S1 subunit, preventing viral attachment and infection.

Tomato CYP94C1 terminates jasmonate signaling during fruit ripening by inactivating bioactive jasmonoyl-L-isoleucine

This study identifies CYP94C1 as a key enzyme in tomato that terminates jasmonate signaling during ripening by converting bioactive JA-Ile to an inactive form, thereby reducing susceptibility to necrotrophic pathogens.

Genetic control of cell layer interactions in plants via tissue mechanics

The paper shows that brassinosteroid genes control tissue growth coordination in plants by modulating mechanical constraints between cell layers.

DESIGN OF A CHIMERIC ACE-2/Fc-SILENT FUSION PROTEIN WITH ULTRAHIGH AFFINITY AND NEUTRALIZING CAPACITY FOR SARS-CoV-2 VARIANTS

This paper designs a chimeric ACE-2/Fc-silent fusion protein with ultra-high affinity and neutralizing capacity against multiple SARS-CoV-2 variants.

ATP-releasing SWELL1 channel in spinal microglia contributes to neuropathic pain

This study identifies VRAC as an ATP-releasing channel in microglia contributing to neuropathic pain and shows dicumarol inhibits it, reducing pain behaviors in mice.

Characterization of Three Variants of SARS-CoV-2 in vivo Shows Host-Dependent Pathogenicity in Hamsters

This study compares the pathogenicity of three SARS-CoV-2 variants in different animal models, showing host-dependent outcomes and the importance of model selection.

The metabolite alpha-ketobutyrate increases health and life spans by activating AMPK

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

Suppression of transposon mobilization by m6A-mediated RNA sequestration in stress granules

This study shows that m6A RNA methylation sequesters transposon RNA in stress granules, preventing mobilization, and that demethylation by AtALKBH9B allows transposon activation.

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.

Epigenetic MRI: Noninvasive Imaging of DNA Methylation in the Brain

This paper introduces eMRI, a noninvasive method to image DNA methylation in the brain, revealing regional differences in global DNA methylation in pigs.

Single-cell transcriptomic profiling of healthy and fibrotic adult zebrafish liver reveals conserved cell identities and stellate cell activation phenotypes with human liver

This study uses scRNA-seq to compare healthy and fibrotic adult zebrafish liver with human liver, identifying conserved cell identities and fibrosis-related gene expression patterns.

Constrained evolutionary paths to macrolide resistance in a Neisseria commensal converge on ribosomal genes through sequence duplication

This study identifies azithromycin resistance mutations in Neisseria elongata through experimental evolution, showing convergence on ribosomal genes via duplication and assessing their potential for horizontal transfer to N. gonorrhoeae.

In Vivo CRISPR Screens Identify E3 Ligase Cop1 as a Modulator of Macrophage Infiltration and Cancer Immunotherapy Target

The paper identifies Cop1 as a modulator of macrophage infiltration and cancer immunotherapy in TNBC by using in vivo CRISPR screens and multi-omics analyses.

The study of lumbar ligamentum flavum hypertrophy induced in bipedal mice

This study induces bipedal posture in mice to create a model of lumbar ligamentum flavum hypertrophy and shows increased stress leads to degeneration.

The PIF1-MIR408-Plantacyanin Repression Cascade Regulates Light Dependent Seed Germination

The paper identifies a PIF1-MIR408-PLC repression cascade that links light-induced PIF1 degradation to hormonal changes, regulating seed germination in Arabidopsis.

Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma

This study identifies TIGAR as a driver of metabolic remodeling in ESCC, showing that targeting the glutamine pathway improves therapeutic outcomes in TIGAR-overexpressed tumors.

Plasma-derived HIV Nef+ exosomes persist in ACTG384 study participants despite successful virological suppression.

The paper measures Nef+ exosomes in HIV+ patients on ART and finds they persist despite viral suppression and correlate with CD4 recovery patterns.

ALI-1, candidate gene of B1 locus, is associated with awn length and grain weight in common wheat

This study identifies ALI-1 as a candidate gene for the B1 locus, showing its role in regulating awn length and grain weight in wheat through cytokinin suppression.

Volumetric two-photon imaging in live cells and embryos via axially gradient excitation

This paper introduces a gradient two-photon microscopy technique that enables rapid volumetric imaging with reduced phototoxicity by using two axially gradient excitation beams.

Strategies to improve photosynthetic nitrogen-use efficiency with no yield penalty: lessons from late-sown winter wheat

This study shows that late-sown winter wheat improves canopy photosynthetic nitrogen-use efficiency without reducing yield by optimizing nitrogen allocation to specific leaves and enhancing photosynthetic capacity.