D. Hornburg

This paper demonstrates that nanoparticle-based proteomics workflows enable accurate and scalable deep plasma proteomics with high precision and statistical power for biomarker discovery.

The paper develops a method using engineered nanoparticles to enhance plasma proteome coverage by optimizing protein-NP interactions and competition, resulting in deeper and more consistent proteomic profiling.

This study shows that amyloid-like aggregates impair lysosomal function in neurons by sequestering AP-31, leading to neurotoxicity.