The Tec kinase ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during early T cell activation to regulate graded gene induction
M. P. Gallagher, J. M. Conley, P. Vangala, A. Reboldi, M. Garber, L. J. Berg
This study shows ITK differentially optimizes NFAT, NF-κB, and MAPK signaling during T cell activation, leading to graded gene induction based on TCR signal strength.
bioRxiv · Nov 12, 2020Immunology