G. P. Nolan

This study reveals that cellular differentiation drives intratumor heterogeneity in B-cell lymphomas, with distinct maturation states associated with different survival outcomes.

MAPS provides pathologist-level cell type annotation from spatial proteomics data using machine learning, outperforming existing methods in speed and accuracy.

This study uses multi-omics analysis to show coordinated changes in epithelial, stromal, and immune compartments during Barrett's Esophagus progression to adenocarcinoma, revealing early appearance of cancer-associated fibroblasts and immunosuppressive microenvironment.

The paper identifies distinct macrophage niches in human breast and colon tissues using single-cell RNA sequencing and imaging, linking their spatial distribution to functional roles.

The paper constructs a single cell spatial temporal atlas of skeletal muscle to reveal cellular neighborhoods involved in regeneration and their disruption in aging.

This study shows that ALDH3A1 deficiency causes mitochondrial dysfunction and impairs salivary gland stem cell self-renewal, differentiation, and survival.

This study shows SARS-CoV-2 infects human adipose tissue, causing inflammation linked to severe COVID-19 outcomes in obese individuals.

The paper develops a method to track subclonal tumor patch behaviors using spatial epitope barcoding and imaging, revealing emergent properties in cancer cell states.

The paper develops PANINI-MIBI to analyze DNA, RNA, and protein in SIV-infected tissues, revealing IL10 upregulation and macrophage polarization linked to viral latency.

This study integrates plasma proteomics and single-cell immune features to classify COVID-19 severity and identify biological signatures of disease progression.

This study uses single-cell transcriptomics and protein profiling to analyze EBOV infection in rhesus monkeys, revealing changes in immune cell dynamics and viral/host gene expression.

This study shows JUN activation in fibroblasts drives fibrosis and modulates immunity, with therapeutic potential through targeting IL-6, CD47, and PD-L1.

This study shows B lymphocytes can undergo multiple mitosis-independent divisions after the first mitosis, driven by unique G1 phase characteristics and limited by apoptosis, with Birc5 playing an essential role.

The paper uses integrated proteomic and metabolic single-cell assays to identify two distinct adaptive pathways in BRAF-mutant melanoma cells during drug treatment.

The paper identifies cellular neighborhoods in colorectal cancer that correlate with antitumoral immunity and patient survival.

This paper uses mass cytometry to analyze MDS patient samples, identifying abnormal surface markers and differentiation patterns not detectable with traditional methods.

The paper identifies TNFAIP3 variants in humans, Denisovans, and mice that modulate A20 phosphorylation, revealing a genetic mechanism for balancing immunity and microbial tolerance.

The paper screens monoclonal antibodies for cross-reactivity in non-human primates and develops immunophenotyping panels for CyTOF.

The paper compares immunological differences between humans, mice, and non-human primates using CyTOF mass cytometry, identifying species-specific immune responses and correlations with viral serostatus.

The paper profiles immune cell responses in humans to identify sex-specific signaling patterns and provides reference ranges for immune markers.