C. Turner

Alzheimer's disease induced neurons bearing PSEN1 mutations exhibit reduced excitability

This study investigates how PSEN1 mutations in Alzheimer's disease affect neuronal excitability using iPSC-derived neurons and finds reduced excitability and altered Kv/Nav channel currents in mutant neurons.

C. elegans display antipathy behavior towards food after contemporaneous integration of nutritional needs and dietary lipid availability

This study identifies molecular mechanisms by which C. elegans avoid Methylobacterium after ingestion, integrating lipid metabolism and dietary needs to influence food preference.

Huntingtin is an RNA-binding protein and participates in NEAT1-mediated paraspeckles

This study identifies huntingtin as an RNA-binding protein that interacts with G-rich RNA sequences, including those in the NEAT1 paraspeckle lncRNA.

ATP1A1-linked diseases require a malfunctioning protein product from one allele

The paper investigates whether haploinsufficiency from protein-null ATP1A1 variants causes disease, finding that Atp1a1+/- mice are phenotypically normal and a human with a null variant shows no disease features.

Cysteine Restriction-Specific Effects of Sulfur Amino Acid Restriction on Lipid Metabolism

This study shows that cysteine restriction, not methionine restriction, drives anti-adiposity effects of sulfur amino acid restriction by increasing serinogenesis and altering metabolic pathways.

Deep learning-based quantification of arbuscular mycorrhizal fungi in plant roots

AMFinder uses deep learning to automatically quantify arbuscular mycorrhizal fungi colonisation in plant roots, improving accuracy and reproducibility over manual methods.

Loss of flavin adenine dinucleotide (FAD) impairs sperm function and male reproductive advantage in C. elegans.

This study shows that reduced FAD levels due to impaired mitochondrial proline catabolism in C. elegans males leads to sperm dysfunction and reduced reproductive fitness, which can be reversed by restoring FAD levels.