Author

G. Dewson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 1 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:development & morphogenesis· 2 Research Focus:drug response / drug discovery· 2 Assay:proteomics· 2 Research Focus:benchmarking· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

G. Lessene· 3 shared A. K. Voss· 2 shared A. Strasser· 2 shared D. C. S. Huang· 2 shared D. Komander· 2 shared M. F. van Delft· 2 shared M. J. Herold· 2 shared P. E. Czabotar· 2 shared

Activity by Year

2018-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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3 shared papersCell Biology

G. Lessene

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Molecular definition of the BAK:VDAC2 interaction as a target to manipulate apoptosis

Z. Yuan, M. F. van Delft, M. X. Li, F. Sumardy, B. J. Smith, D. C. S. Huang, G. Lessene, Y. Khakham, R. Jin, S. He, N. A. Smith, R. Birkinshaw, P. E. Czabotar, G. Dewson

This study identifies key residues in the BAK:VDAC2 interaction, showing that disrupting this interaction can inhibit or promote apoptosis depending on the context.

bioRxiv · Dec 13, 2023 · PreprintCell Biology

Relative importance of MCL-1's Anti-Apoptotic versus Non-Apoptotic Functions in vivo

K. Brinkmann, K. McArthur, A. Tee, A. J. Kueh, S. Malelang, V. Wimmer, L. Gibson, C. L. Rowe, P. Arandjelovic, G. Dewson, T. Putoczki, P. Bouillet, N. Fu, T. Thomas, M. J. Herold, , A. Strasser

This study replaces MCL-1 with other anti-apoptotic proteins in mice to determine the relative importance of MCL-1's anti-apoptotic versus non-apoptotic functions in development and physiology.

bioRxiv · Aug 14, 2023 · PreprintCell Biology

Trabid patient mutations impede the axonal trafficking of adenomatous polyposis coli to disrupt neurite growth

D. Frank, M. Bergamasco, M. Mlodzianoski, A. Kueh, E. Tsui, C. Hall, G. Kastrappis, A. K. Voss, C. McLean, M. C. Faux, K. Rogers, B. Tran, E. Vincan, D. Komander, G. Dewson, H. Tran

This study identifies Trabid mutations that disrupt APC trafficking and neurite growth by impairing DUB activity or STRIPAK binding, leading to neurodevelopmental defects.

bioRxiv · Jul 17, 2023Cell Biology

E3 ubiquitin ligase MARCHF5 controls BAK apoptotic activity independently of BH3-only proteins

G. Dewson, A. S. Huang, H. S. Chin, B. Reljic, T. M. Djajawi, I. K. Tan, D. A. Stroud, D. C. S. Huang, M. F. van Delft

This study identifies MARCHF5 as a regulator of BAK apoptotic activity through ubiquitin ligase activity, independent of BH3-only proteins, and shows its role in drug resistance.

bioRxiv · Jan 4, 2022 · PreprintCell Biology

Mechanism and inhibition of SARS-CoV-2 PLpro

T. Klemm, G. Ebert, D. J. Calleja, C. C. Allison, L. W. Richardson, J. P. Bernardini, B. G. C. Lu, N. W. Kuchel, C. Grohmann, Y. Shibata, Z. Y. Gan, J. P. Cooney, M. Doerflinger, A. E. Au, T. R. Blackmore, , D. Komander

This study investigates SARS-CoV-2 PLpro's mechanism and identifies non-covalent inhibitors with antiviral activity.

bioRxiv · Jun 18, 2020Biochemistry

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

M. S. Brennan, C. Chang, G. Dewson, L. Tai, G. Lessene, A. Strasser, G. L. Kelly, M. J. Herold

This study develops a humanized Mcl-1 mouse model to evaluate MCL-1 inhibitors, showing improved sensitivity to S63845 and effective tumor remission in pre-clinical trials.

bioRxiv · Jun 14, 2018Cancer Biology