Author

L. Tai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

A. Strasser· 3 shared A. J. Kueh· 2 shared G. L. Kelly· 2 shared M. A. Potts· 2 shared M. J. Herold· 2 shared M. Pal· 2 shared S. Mizutani· 2 shared A. Garnham· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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3 shared papersCancer Biology

A. Strasser

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis

M. Herold, M. A. Potts, S. Mizutani, A. Garnham, C. S. N. Li-Wai-Suen, A. J. Kueh, L. Tai, M. Pal, A. Strasser

This study shows that deleting TFAP4 in E-MYC transgenic mice accelerates lymphoma development by blocking B cell differentiation.

Cell Death & Differentiation · Jun 1, 2023Peer-reviewedCancer Biology

In-cell structural insight into the stability of sperm microtubule doublet

L. Tai, G. Yin, X. Huang, Y. Zhu, F. Sun

The paper uses cryo-electron tomography to determine the in-cell structure of mouse sperm microtubule doublets, revealing their molecular architecture and stability mechanisms.

bioRxiv · May 30, 2023Cell Biology

Genome-wide in vivo CRISPR screens identify GATOR1 as a potent tumor suppressor in MYC-driven lymphomagenesis

M. A. Potts, S. Mizutani, Y. Deng, S. Vaidyanathan, K. Ting, G. Giner, S. Shruti, Y. Liao, S. Diepstraten, A. J. Kueh, M. Pal, G. Healey, L. Tai, Z. Wang, C. Koenig, , M. J. Herold

The paper identifies GATOR1 as a tumor suppressor in MYC-driven lymphomagenesis using in vivo CRISPR screens and shows its sensitivity to mTOR inhibitors.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Humanized Mcl-1 mice enable accurate pre-clinical evaluation of MCL-1 inhibitors destined for clinical use

M. S. Brennan, C. Chang, G. Dewson, L. Tai, G. Lessene, A. Strasser, G. L. Kelly, M. J. Herold

This study develops a humanized Mcl-1 mouse model to evaluate MCL-1 inhibitors, showing improved sensitivity to S63845 and effective tumor remission in pre-clinical trials.

bioRxiv · Jun 14, 2018Cancer Biology