ImmunologybioRxivPreprint
The inflammasome-activated cytokine IL-1 is targeted for ubiquitylation and proteasomal degradation to limit its inflammatory potential
S. Vijayaraj, R. Feltham, M. Rashidi…·J. E. Vince
This study shows that IL-1β is ubiquitylated and degraded to limit its inflammatory activity, with specific ubiquitin modifications and electrostatic interactions playing key roles.
DOI 10.1101/2021.03.15.435390