In-cell chemical crosslinking identifies hotspots for p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilization
Y. Liu, M. J. Trnka, L. He…·M. A. Correia
This study identifies p62-IκBα interaction hotspots using in-cell crosslinking and proteomics, revealing p62 stabilizes IκBα to limit NF-κB activation and prevent liver inflammation.