A. Burlingame

Assessing Heterogeneity in the N-Telopeptides of Type I Collagen by Mass Spectrometry

The paper develops a method to identify N-terminal cross-linked peptides from collagen I in Achilles tendon using mass spectrometry, revealing differences in cross-links in bovine pulmonary hypertension.

Non-specific recognition of histone modifications by H3K9bhb antibody

The paper shows that the H3K9bhb antibody also recognizes other modifications, including acetylations, which can affect interpretations of gene regulation data.

In-cell chemical crosslinking identifies hotspots for p62-IκBα interaction that underscore a critical role of p62 in limiting NF-κB activation through IκBα-stabilization

This study identifies p62-IκBα interaction hotspots using in-cell crosslinking and proteomics, revealing p62 stabilizes IκBα to limit NF-κB activation and prevent liver inflammation.

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

The paper determines the structure of VGLUT2 with a glutamate analog bound, revealing mechanisms of substrate recognition, electrostatic interactions, and palmitoylation's role in transporter retrieval.

Endothelial-secreted Endocan protein acts as a PDGFR alpha ligand and regulates vascularity, radioresistance, and regional phenotype in glioblastoma

This study identifies Endocan as an endothelial-secreted ligand for PDGFR alpha that promotes GBM vascularity, radioresistance, and phenotypic diversity.

TMEM16K is an interorganelle regulator of endosomal sorting

This study identifies TMEM16K as an interorganelle regulator of endosomal sorting, linking its lipid scrambling activity to neuromuscular function and neurodegeneration.

Characterization of Prenylated C-terminal Peptides Using a Novel Capture Technique Coupled with LCMS

This paper introduces a novel capture technique using mixed disulfide-functionalized resins to directly isolate and characterize prenylated C-terminal peptides from tissue samples via LCMS without metabolic labeling.