Author

S. Guan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1 Immunology· 1 Microbiology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:DNA methylation· 3 Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Y. Liu· 2 shared A. A. Heidecker· 1 shared A. Casini· 1 shared A. D. T. Barrett· 1 shared A. L. Burlingame· 1 shared A. P. C. Lim· 1 shared A. Poethig· 1 shared B. Aikman· 1 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersImmunology

Y. Liu

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Author profile →

5 papers

Recent·Most cited

Organometallic Pillarplexes that bind DNA 4-way Holliday Junctions and Forks.

J. S. Craig, L. Melidis, H. D. Williams, S. J. Dettmer, A. A. Heidecker, P. J. Altmann, S. Guan, C. Campbell, D. F. Browning, R. K. O. Sigel, S. Johannsen, R. T. Egan, B. Aikman, A. Casini, A. Poethig, M. J. Hannon

This paper demonstrates that Au pillarplexes bind open DNA 4-way junctions and rearrange them into Y-shaped forks, with antiproliferative activity in human cells.

bioRxiv · Jan 4, 2023Biochemistry

Trans-species microRNA loci in the parasitic plant Cuscuta campestris have a U6-like snRNA promoter

C. Hudzik, S. Maguire, S. Guan, J. Held, M. J. Axtell

The paper identifies a U6-like snRNA promoter in Cuscuta campestris microRNAs that are induced at the parasite-host interface and may enable trans-species activity.

bioRxiv · Jul 6, 2022Plant Biology

Respiratory mucosal vaccination of peptide-poloxamine-DNA nanoparticles provides complete protection against lethal SARS-CoV-2 challenge

S. Sun, E. Li, G. Zhao, J. Tang, Q. Zuo, L. Cai, C. Xu, C. Sui, Y. Ou, C. Liu, H. Li, Y. Ding, C. Li, D. Lu, W. Zhang, , S. Guan

This study shows that peptide-poloxamine-DNA nanoparticles provide complete protection against lethal SARS-CoV-2 challenge through robust mucosal immunity.

bioRxiv · May 29, 2022Immunology

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the optimal therapeutic efficacy of the antibody

C. E. Z. Chan, S. G. K. Seah, D. H. Chye, S. Massey, M. Torres, A. P. C. Lim, S. K. K. Wong, J. J. Y. Neo, P. S. Wong, J. H. Lim, G. S. L. Loh, D. L. Wang, J. D. Boyd-Kirkup, S. Guan, D. Thakkar, , B. J. Hanson

The paper identifies SC31, a potent SARS-CoV-2 neutralizing antibody, and shows that its Fc-mediated effector functions are critical for its therapeutic efficacy in vivo.

bioRxiv · Oct 26, 2020Microbiology

A NOVEL MECHANISM FOR NF-κB-ACTIVATION VIA IκB-AGGREGATION: IMPLICATIONS FOR HEPATIC MALLORY-DENK-BODY INDUCED INFLAMMATION

Y. Liu, M. J. Trnka, S. Guan, D. Kwon, D.-H. Kim, J.-J. Chen, P. A. Greer, A. L. Burlingame, M. A. Correia

This study identifies a novel mechanism of NF-κB activation through IκB sequestration into insoluble aggregates along with aggregation-prone proteins in MDB-inducing models.

bioRxiv · Mar 21, 2019Cell Biology