M. Jechlinger

Pulsed stimulated Brillouin microscopy enables high-sensitivity mechanical imaging of live and fragile biological specimens

This paper introduces pulsed stimulated Brillouin microscopy to improve mechanical imaging of live biological specimens with reduced phototoxicity and enhanced signal-to-background ratio.

Light and electron microscopy continuum-resolution imaging of 3D cell cultures

The paper presents a multi-scale imaging approach for 3D cell cultures that integrates light and electron microscopy to analyze subcellular structures in organoids.

Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples

The paper presents a method to precisely target FIB-SEM acquisition of fluorescently labeled cells in large samples using fluorescence preservation and confocal imaging.

In-vivo monitoring and quantification of breast cancer growth dynamics with non-invasive intravital mesoscopic fluorescence molecular tomography

This study introduces a non-invasive imaging method to quantitatively track tumor growth in living mice, finding that tumor volume is not well correlated with cell quantity.

Oncogenic memory underlying minimal residual disease in breast cancer

This study identifies metabolic features of minimal residual disease (MRD) cells in breast cancer that resemble the tumor state, suggesting oncogenic memory and potential therapeutic targets.

Tracking the cells of tumor origin in breast organoids by light sheet microscopy

The paper develops a methodology combining breast organoids and light-sheet imaging to track cell fates and finds that small groups of transformed cells form tumors while isolated cells do not.