P. Ronchi

Plasmodium falciparum impairs Ang-1 secretion by pericytes in a 3D brain microvessel model

This paper shows that Plasmodium falciparum impairs Ang-1 secretion by pericytes in a 3D brain microvessel model, leading to vascular dysfunction that can be partially reversed with Ang-1 or AKB-9778.

In-cell structure and snapshots of copia retrotransposons in intact tissue by cryo-electron tomography

This study uses cryo-ET to visualize copia retrotransposon structure in Drosophila cells, revealing nuclear clustering and size selection during gametogenesis.

BRD4-mediated epigenetic regulation of endoplasmic reticulum-mitochondria contact sites is governed by the mitochondrial complex III

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

Adhesion energy controls lipid binding-mediated endocytosis

The paper shows that multivalent lipid binding by globular particles induces membrane deformation and clathrin-independent endocytosis, with adhesion energy determining the threshold for internalization.

Life cycle-coupled evolution of mitosis in close relatives of animals

The paper investigates mitotic strategies in Ichthyosporea, showing divergence towards fungal-like closed or animal-like open mitosis, with multinucleated life cycles favoring closed mitosis.

Targeted volume Correlative Light and Electron Microscopy of an environmental marine microorganism

The paper demonstrates a method to target and analyze the 3D ultrastructure of a photosynthetic marine microorganism using correlative light and electron microscopy.

Light and electron microscopy continuum-resolution imaging of 3D cell cultures

The paper presents a multi-scale imaging approach for 3D cell cultures that integrates light and electron microscopy to analyze subcellular structures in organoids.

Fluorescence-based 3D targeting of FIB-SEM acquisition of small volumes in large samples

The paper presents a method to precisely target FIB-SEM acquisition of fluorescently labeled cells in large samples using fluorescence preservation and confocal imaging.

In cell architecture of the nuclear pore complex and snapshots of its turnover

The paper uses structural biology and yeast genetics to study NPC architecture and turnover in yeast cells, revealing new insights into mRNA export and autophagy mechanisms.

Spatial control of nucleoporin assembly by Fragile X-related proteins

This paper shows that FXR proteins and dynein help localize nucleoporins to the nuclear envelope and prevent their cytoplasmic aggregation, which affects nuclear morphology and G1 cell cycle progression.

An ESCRT-LEM domain inner nuclear membrane protein surveillance system is poised to directly monitor the integrity of the nuclear envelope barrier and nuclear transport system

The paper identifies a surveillance system in yeast that detects and seals nuclear envelope damage through ESCRT and inner nuclear membrane proteins.

Tunneling nanotubes contribute to the stroma-mediated imatinib resistance of leukemic cells

This study shows that tunneling nanotubes (TNTs) mediate stroma-mediated imatinib resistance in leukemic cells by transferring survival proteins.

Alpha-synuclein fibrils induce autophagy in microglial cells as a consequence of lysosomal damage.

This study shows that alpha-synuclein fibrils cause lysosomal damage and autophagy in microglial cells, leading to mitochondrial dysfunction and cell death.