C. Tischer

Pervasive sublethal effects of agrochemicals as contributing factors to insect decline

This study shows sublethal agrochemical exposure harms insect behavior, survival, and reproduction, with effects amplified by temperature changes, contributing to insect population decline.

Dextromethorphan inhibits collagen transport in the endoplasmic reticulum eliciting an anti-fibrotic response in ex-vivo and in vitro models of pulmonary fibrosis

This study shows Dextromethorphan reduces collagen deposition in fibrotic models by inhibiting collagen trafficking in the endoplasmic reticulum.

The Image Data Explorer: interactive exploration of image-derived data

The paper introduces the Image Data Explorer, a web tool for interactive exploration of image-derived data in bioimage analysis.

CLEMSite, a software for automated phenotypic screens using light microscopy and FIB-SEM

The paper introduces CLEMSite, a software tool for automated phenotypic screens using light microscopy and FIB-SEM, enabling high-throughput volume acquisition with reduced operator supervision.

Microscopy-based assay for semi-quantitative detection of SARS-CoV-2 specific antibodies in human sera

The paper develops a semi-quantitative microscopy-based assay to detect SARS-CoV-2 specific antibodies in human sera, providing a sensitive and specific method for serological analysis.

Dense encoding of developmental regulatory information may constrain evolvability

The paper investigates the evolutionary potential of regulatory changes in developmental enhancers by analyzing mutations in Drosophila melanogaster, finding that most mutations affect gene expression and suggest dense regulatory information that may constrain evolvability.

Whole-body integration of gene expression and single-cell morphology

The paper integrates gene expression and single-cell morphology in Platynereis dumerilii to identify spatially coherent cell groups defined by transcription factors.

Multiomic and quantitative label-free microscopy-based analysis of ex vivo culture and TGFbeta1 stimulation of human precision-cut lung slices

The paper uses multiomic and microscopy techniques to study fibrosis in human lung slices, showing increased collagen deposition with TGFbeta1 stimulation and a novel SHG-based method to quantify it.

Genetic screening identifies a SUMO protease dynamically maintaining centromeric chromatin and the associated centromere complex

The paper identifies SENP6 as a SUMO protease critical for maintaining centromeric chromatin and the centromere complex through dynamic SUMO regulation.

Tracking the cells of tumor origin in breast organoids by light sheet microscopy

The paper develops a methodology combining breast organoids and light-sheet imaging to track cell fates and finds that small groups of transformed cells form tumors while isolated cells do not.