P. Sarkar

NONEXPRESSOR OF PATHOGENESIS-RELATED GENES control Huanglongbing tolerance by regulating immune balance in citrus plants

This study shows that overexpressing AtNPR1 or silencing AtNPR3/AtNPR4 orthologs in citrus enhances HLB tolerance by regulating immune balance and reducing callose and ROS accumulation.

IL6 mediated cFLIP downregulation increases the migratory and invasive potential of triple negative breast cancer cells

The paper shows that IL6-mediated cFLIP downregulation enhances metastasis in triple negative breast cancer by reducing autophagy.

Multiplexed gene editing with a multi-intron containing Cas9 gene in citrus

This paper introduces a multiplex gene editing system in citrus using a multi-intron Cas9 gene and gRNA-tRNA arrays to target the PDS gene, improving editing efficiency in Carrizo citrange and Duncan grapefruit.

Direct ionic stress sensing and mitigation by the transcription factor NFAT5

This study identifies NFAT5 as a direct sensor and effector of ionic stress in animal cells, showing it forms condensates to activate genes restoring ion balance.

Differential Carbonic Anhydrase Activities Control EBV-Induced B-Cell Transformation and Lytic Cycle Reactivation

This study shows that differential carbonic anhydrase activities regulate EBV-induced B-cell transformation and lytic cycle reactivation through transcriptional control by EBNA2 and BZLF1.

Multi-modal Imaging of Disease Progression in TH-MYCN Mouse Models of Neuroblastoma

This study uses multi-modal imaging to compare tumor progression and vascular architecture in TH-MYCN transgenic and implanted neuroblastoma models.

Phenotypic plasticity of ER+ breast cancer in the bone microenvironment

The paper shows that the bone microenvironment induces endocrine resistance in ER+ breast cancer metastases through epigenomic reprogramming mediated by EZH2.

Differential levels of dermatan sulfate generate distinct Collagen I gel architectures

This study examines how varying concentrations of dermatan sulfate affect Collagen I gel architecture using imaging techniques.

Cryo-Electron tomography 3D structure and nanoscale model of Arabidopsis thaliana cell wall

Cryo-electron tomography and mechanical simulations revealed cell wall 3D architecture, optimized for flexibility/ductility.

Phenotypic consequences of RNA polymerase dysregulation in Escherichia coli

This study shows that perturbing RNA polymerase activity in E. coli leads to biphasic growth and increased tolerance to antibacterial stresses.