M. Kjaergaard

Oxygen partitioning into biomolecular condensates is governed by protein density

The paper investigates oxygen partitioning into biomolecular condensates and finds that oxygen concentration varies with protein density and chain length.

Enhanced hexamerization of insulin via assembly pathway rerouting revealed by single particle studies

This study uses single molecule fluorescence microscopy to observe insulin self-assembly and disassembly, revealing new pathways and how additives influence oligomer formation.

The optimal docking strength for reversibly tethered kinases

This study determines the optimal docking strength for kinases to enhance phosphorylation rates under specific conditions.

Estimation of effective concentrations enforced by complex linker architectures using conformational ensembles.

The paper estimates effective concentrations in complex linker architectures using conformational ensembles and shows that folded domains can enhance effective concentrations compared to fully disordered linkers.

A paired liver biopsy and plasma proteomics study reveals circulating biomarkers for alcohol-related liver disease

This study identifies circulating proteomic biomarkers for alcohol-related liver disease using paired liver biopsy and plasma proteomics, showing improved performance over existing tests.

Histidine-rich Ca2+-binding protein stimulates the transport cycle of SERCA through a conformation-dependent fuzzy complex.

This study shows HRC stimulates SERCA by binding in a conformation-dependent fuzzy complex, stabilizing the end of the SERCA transport cycle.

Nanoscale spatial dependence of avidity in an IgG1 antibody

This study investigates the nanoscale spatial dependence of avidity in IgG1 antibodies by using coiled-coils to control epitope spacing and measuring avidity enhancement.

The crystal structure of the Ca2+-ATPase 1 from Listeria monocytogenes reveals a pump primed for dephosphorylation

The paper presents crystal structures of LMCA1, revealing its primed state for dephosphorylation and a single Ca2+-binding site, with insights into its transport mechanism.

Intrinsically disordered linkers control tethered kinases via effective concentration

This study shows that phosphorylation kinetics of tethered kinases depend on the length of intrinsically disordered linkers and substrate-specific scaling.

Helix formation during the coupled binding and folding of intrinsically disordered proteins monitored by synchrotron-radiation circular dichroism spectroscopy

The paper uses synchrotron-radiation circular dichroism to study helix formation during the binding of intrinsically disordered proteins, revealing kinetic phases and structural intermediates.

Linker dependence of avidity in multivalent interactions between disordered proteins

This study experimentally examines how linker length affects avidity in bivalent protein interactions and finds that avidity decreases less than predicted by theoretical models.

Effective concentrations enforced by intrinsically disordered linkers are governed by polymer physics

The paper measures effective concentrations of disordered protein linkers and shows they follow polymer physics models, with compaction influenced by charge type and aromatic residues.