A. Garg

Dilated cardiomyopathy-associated skeletal muscle actin (ACTA1) mutation R256H disrupts actin structure and function and causes cardiomyocyte hypocontractility

This study shows that the ACTA1 R256H mutation disrupts actin structure and function in cardiomyocytes, leading to reduced contractility and a likely causative role in dilated cardiomyopathy.

Anti-cancer drug Tamoxifen interferes with Mycobacterium tuberculosis PhoPR mediated signaling and inhibits mycobacterial growth

This study identifies Tamoxifen as an inhibitor of Mycobacterium tuberculosis PhoPR signaling, reducing bacterial growth and disrupting downstream gene expression.

Ser/Thr Phosphorylation of Mycobacterium tuberculosis Type II Rel TA module by Protein Kinase K interferes with toxin neutralization: A novel mode of TA regulation.

This study identifies Ser/Thr phosphorylation by PknK as a novel regulatory mechanism for Type II TA modules in M. tuberculosis, disrupting toxin-antitoxin interactions.

Treatment with anti-inflammatory viral serpin modulates immuno-thrombotic responses and improves outcomes in SARS-CoV-2 infected mice

This study shows that PEGSerp-1 treatment reduces inflammation and improves outcomes in SARS-CoV-2 infected mice by modulating immuno-thrombotic responses.

Design Principles for Inflammasome Inhibition by Pyrin-Only-Proteins

This study identifies how pyrin-only-proteins inhibit inflammasomes by targeting different filament assembly steps, revealing their target redundancy and inhibition mechanisms.

Insights into the Human Gut Virome by Sampling a Population from the Indian Subcontinent

This study analyzes the gut virome of an Indian population using metagenomics, identifying novel viral families and a core virome composition.

The colonial legacy of herbaria

The paper analyzes 85 million herbarium records to show colonial legacies in plant specimen distribution, revealing disparities between biodiversity hotspots and where specimens are housed.

One mucosal administration of a live attenuated recombinant COVID-19 vaccine protects non-human primates from SARS-CoV-2

This study shows that a single mucosal dose of the live attenuated RSV-based vaccine MV-014-212 protects non-human primates from SARS-CoV-2 infection by reducing viral shedding and inducing neutralizing antibodies.

Variable Mutations at the p53-R273 Oncogeic Hotspot Position Leads to Altered Properties

This study examines how different R273 mutations in p53 affect structural stability, aggregation, and toxicity, revealing distinct molecular mechanisms that may contribute to varied cancer outcomes.