M. Krendel

Loss of Myosin-1e biases MMTV-PyMT induced breast cancer towards a 4 differentiated and secretory state

This study shows that Myo1e depletion in breast cancer tumors shifts them toward a more differentiated, secretory state, while its presence promotes a less-differentiated, pro-tumorigenic state.

Myo1e knockout in the adult podocytes leads to proteinuria but has less severe consequences for kidney function than Myo1e loss during renal development

This study shows that Myo1e loss in adult podocytes causes proteinuria and mild podocyte defects, unlike severe effects seen when Myo1e is lost during renal development.

Theoretical model of efficient phagocytosis driven by curved membrane proteins and active cytoskeleton forces

This paper presents a theoretical model explaining how curved membrane proteins and active cytoskeletal forces drive efficient phagocytosis, showing reduced adhesion strength requirements and faster engulfment.

Steroid-resistant nephrotic syndrome associated MYO1E mutations have differential effects on myosin 1e localization, dynamics, and activity

This study investigates two MYO1E mutations in SRNS patients, showing T119I affects Myo1e localization and D388H reduces ATPase activity and actin translocation.

Phagocytic 'teeth' and myosin-II 'jaw' power target constriction during phagocytosis

The paper uses microscopy and force measurement techniques to show how localized actin and myosin forces drive target constriction during phagocytosis, revealing a distinct mechanism from 2D cell motility.

Human Myosin 1e tail but not motor domain replaces fission yeast Myo1 domains to support myosin-I function during endocytosis

This study shows that the human Myo1e tail can partially rescue endocytosis in fission yeast when combined with the yeast Myo1 motor domain, while the motor domain cannot function in yeast.

Membrane-cytoskeleton mechanical feedback mediated by myosin-I controls phagocytic efficiency

The paper shows that myosin 1e and 1f are required for efficient phagocytosis by regulating adhesion turnover and actin dynamics during phagocytic cup closure.