Author

O. Buzovetsky

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1

Frequent Co-Authors

Y. Xiong· 4 shared J. M. Antonucci· 2 shared K. Knecht· 2 shared L. Wu· 2 shared X. Ji· 2 shared A. A. Duchon· 1 shared B. A. Desimmie· 1 shared C. Liu· 1 shared

Activity by Year

2017-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersBiophysics

Y. Xiong

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The structural basis for cancer drug interactions with the catalytic and allosteric sites of SAMHD1

K. M. Knecht, O. Buzovetsky, C. Schneider, D. Thomas, V. Srikanth, F. Tofoleanu, K. Reiss, N. Ferreiros, G. Geisslinger, V. S. Batista, X. Ji, J. Cinatl, O. T. Keppler, Y. Xiong

This study investigates how cancer drugs interact with SAMHD1's catalytic and allosteric sites, finding that drug efficacy is affected by SAMHD1 activity and that only cladribine-TP induces the active tetramer.

bioRxiv · Apr 6, 2018Biochemistry

SAMHD1 Impairs HIV-1 Gene Expression and Reactivation of Viral Latency in CD4+ T-cells

J. M. Antonucci, S. H. Kim, C. St. Gelais, S. Bonifati, O. Buzovetsky, K. Knecht, A. A. Duchon, Y. Xiong, K. M. Musier-Forsyth, L. Wu

This study shows that SAMHD1 suppresses HIV-1 gene expression and reactivation in CD4+ T-cells by binding to the HIV-1 LTR and inhibiting transcription.

bioRxiv · Feb 23, 2018Microbiology

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.

S. J. Ziegler, C. Liu, M. Landau, O. Buzovetsky, B. A. Desimmie, Q. Zhao, T. Sasaki, R. C. Burdick, V. K. Pathak, K. S. Anderson, Y. Xiong

This study investigates how APOBEC3G selects DNA substrates through structural, biochemical, and functional analyses, revealing key interactions and mechanisms involved in its antiviral activity against HIV-1.

bioRxiv · Dec 16, 2017Biophysics

The SAM domain of mouse SAMHD1 is critical for its activation and regulation

O. Buzovetsky, C. Tang, K. Knecht, J. M. Antonucci, L. Wu, X. Ji, Y. Xiong

This study determines the first crystal structure of full-length mouse SAMHD1 in three nucleotide-bound states, revealing a more complex activation process involving the SAM domain compared to human SAMHD1.

bioRxiv · Oct 24, 2017Biophysics