ZFAND6 is a subunit of a TRAF2-cIAP E3 ubiquitin ligase complex essential for mitophagy
K. Shaikh, M. Bowman, S. M. McCormick, L. Gao, J. Zhang, J. Tawil, A. Kapoor, R. Arav-Boger, Y. B. Choi, A. Pekosz, S. L. Klein, M. Lanza, J. C. Fanburg-Smith, A. Garcia-Sastre, C. C. Norbury, , E. W. Harhaj
This study identifies ZFAND6 as a component of a TRAF2-cIAP E3 ubiquitin ligase complex that regulates mitophagy, maintaining mitochondrial homeostasis and influencing immune responses to viral infection.
bioRxiv · Mar 27, 2024 · PreprintImmunology