Epigenetic vulnerabilities of leukemia harboring inactivating EZH2 mutations
M. Alqazzaz, G. Luciani, V. Vu…·D. Barsyte-Lovejoy
This study identifies epigenetic vulnerabilities in AML and MDS/MPN with EZH2 mutations, showing increased sensitivity to EZH2 and EED inhibitors and upregulation of cell death pathways.