Targeted engagement of β-catenin-Ikaros complexes in refractory B-cell malignancies
K. N. Cosgun, H. Jumaa, M. E. Robinson…·M. Mueschen
This study identifies a unique vulnerability in B-cell malignancies where GSK3β inhibitors disrupt β-catenin-Ikaros complexes, leading to MYC repression and cell death.