L. Ge

SMYD5 is a ribosomal methyltransferase that catalyzes RPL40 lysine methylation to enhance translation output and promote hepatocellular carcinoma

This study identifies SMYD5 as a methyltransferase that modifies RPL40 K22me3, enhancing translation and promoting hepatocellular carcinoma.

The Hippo/YAP Pathway Mediates the De-differentiation of Corneal Epithelial Cells into Functional Limbal Epithelial Stem Cells In Vivo

This study shows corneal epithelial cells can de-differentiate into functional limbal epithelial stem cells in vivo, mediated by the Hippo/YAP pathway, offering a new approach for treating limbal stem cell deficiency.

Human Amniotic Epithelial Cells Promote Chx10-/Pax6+ Muller Glia Subpopulation Reprogramming into Photoreceptor-like Cells

This study identifies a specific Muller glia subpopulation that can be reprogrammed into photoreceptor-like cells through transplantation of human amniotic epithelial cells.

Design-Rules for Stapled Alpha-Helical Peptides with On-Target In Vivo Activity: Application toMdm2/X dual antagonists

The paper develops design rules for stapled alpha-helical peptides to improve in vivo activity and reduce off-target effects, demonstrating significant improvements in potency and safety.

From whole genome to probiotic candidates: a study of potential Lactobacillus strain selection for vaginitis treatment

This study identifies two Lactobacillus strains with probiotic properties for vaginitis treatment using genomic analysis, in vitro tests, and in vivo experiments.

Arabidopsis ORP2A positively regulates glucose signaling by interacting with AtRGS1 and promoting AtRGS1 degradation

Compartmentation of putrescine synthesis in plants

This study identifies the subcellular localization of enzymes involved in putrescine synthesis in plants, revealing compartmentalization in chloroplasts, ER, and mitochondria.

Heterotrimeric G protein α subunit (GPA1) regulates the response to low-nitrogen stress in Arabidopsis by interacting with AtNRT1.4 and AtATG8a

AtGPA1 regulates low-nitrogen stress response in Arabidopsis by interacting with AtNRT1.4 and AtATG8a, affecting nitrate uptake and autophagy.

Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling

This paper identifies macrocyclic peptides that inhibit KRAS signaling by binding to its hydrophobic pocket, showing on-target activity and improved proteolytic stability.

Visualizing sequential compound fusion and kiss-and-run in live excitable cells

The paper visualizes new fusion modes in live neuroendocrine cells and suggests updating exo-endocytosis models.

A new type of ERGIC-ERES membrane contact mediated by TMED9 and SEC12 is required for autophagosome biogenesis

The paper identifies a new ERGIC-ERES membrane contact mediated by TMED9 and SEC12 that is essential for autophagosome biogenesis under stress.

Transcriptome analyses of β-thalassemia -28 (A>G) mutation using isogenic cell models generated by CRISPR/Cas9 and asymmetric single-stranded oligodeoxynucleotides (assODN)

This study uses CRISPR/Cas9 and assODN to create an isogenic cell model of the HBB -28 (A>G) mutation and analyzes its transcriptome effects, revealing altered gene expression and pathway activation.

NbCycB2 represses Nbwo activity via a negative feedback loop in the tobacco trichome development

Deoxynivalenol Promotes Porcine Epidemic Diarrhea Virus Infection and Aggravates Gut Barrier Injury

This study shows that deoxynivalenol (DON) promotes PEDV infection and worsens gut barrier injury by inducing autophagy and impairing innate immunity.

A novel MRI-based finite element modeling method for calculation of myocardial ischemia effect in patients with functional mitral regurgitation.

This paper introduces an MRI-based finite element modeling method to predict myocardial ischemia effects in patients with functional mitral regurgitation, showing successful convergence and agreement with experimental data.

Super-resolution microscopy unveils FIP200-scaffolded, cup-shaped organization of mammalian autophagic initiation machinery

This study uses super-resolution microscopy to reveal the cup-shaped structure of the autophagic initiation machinery, showing FIP200 scaffolds this structure before LC3 lipidation.

Mechanical effects of MitraClip on leaflet stress and myocardial strain in functional mitral regurgitation: A finite element modeling study.

This study uses finite element modeling to show that MitraClip increases leaflet stress and myocardial strain in patients with functional mitral regurgitation and coronary disease, with effects amplified by left ventricular enlargement.

Left ventricular geometry during unloading and the end-systolic pressure volume relationship: Measurement with a modified real-time MRI-based method in normal sheep.

This study measures left ventricular geometry and ESPVR during vena cava occlusion in sheep using real-time MRI and a modified segmentation method, revealing non-linear responses and chamber collapse.

The mineralization characteristics of organic carbon and particle composition analysis in reconstructed soil with different proportions of soft rock and sand

This paper examines how varying proportions of soft rock and sand affect soil organic carbon mineralization and particle composition, finding that ratios of 1:5 to 1:2 enhance organic carbon accumulation and stability.

Remodeling of ER-exit sites initiates a membrane supply pathway forautophagosome biogenesis

The paper identifies a pathway where FIP200 and CTAGE5 remodel ER-exit sites to generate COPII vesicles that contribute to autophagosome biogenesis during starvation.