M. McReynolds

This study identifies structural and metabolic changes in human heart failure using SBF-SEM and metabolomic analyses.

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

This study identifies NADK upregulation as a critical metabolic adaptation enabling breast cancer metastasis by enhancing NADPH production and oxidative stress resistance.