Author

P. Katti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7 Cell Biology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 10 Approach:experimental assay· 7 Assay:imaging· 5 Organism:Drosophila· 4 Organism:mouse· 4 Approach:microscopy & imaging analysis· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2

Frequent Co-Authors

B. Glancy· 10 shared K. Neikirk· 8 shared M. Mungai· 8 shared Z. Vue· 8 shared A. Hinton· 7 shared A. Marshall· 6 shared E. D. Abel· 5 shared E. Garza Lopez· 5 shared

Activity by Year

2021-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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10 shared papersBiophysics

B. Glancy

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Author profile →

11 papers

Recent·Most cited

3D Mitochondrial Structure in Aging Human Skeletal Muscle: Insights into MFN-2 Mediated Changes

E. Scudese, Z. Vue, P. Katti, A. Marshall, M. Demirci, L. Vang, E. Garza Lopez, K. Neikirk, H. Le, D. Stephens, D. D. Hall, R. Rostami, T. Rodman, K. Kabugi, J.-q. Shao, , A. Hinton

This study investigates age-related changes in mitochondrial 3D structure in human skeletal muscle and shows that exercise can restore mitochondrial integrity through mitofusin 2.

bioRxiv · Nov 13, 2023Biophysics

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

A. Crabtree, K. Neikirk, A. Marshall, L. Vang, D. Stephens, B. Shao, E. Garza-Lopez, J. Lam, B. Rodriguez, M. Mungai, J. Stanley, D. Dean, J. Gaddy, E. Scudese, M. Sweetwyne, , A. Hinton

This study uses 3D electron microscopy to analyze mitochondrial cristae morphology in mouse brown adipose tissue across aging, finding significant structural changes in aged tissue.

bioRxiv · May 12, 2023Biophysics

ATF4 Dependent Increase in Mitochondrial-Endoplasmic Reticulum Tethering Following OPA1 Deletion in Skeletal Muscle

A. Hinton, P. Katti, M. Mungai, D. Hall, O. Koval, J. Shao, Z. Vue, E. G. Lopez, R. Rostami, K. Neikirk, J. Ponce, J. Streeter, B. Schickling, S. Bacevac, C. Grueter, , E. D. Abel

This study shows that OPA1 deficiency in skeletal muscle increases MERC formation via ATF4, affecting calcium exchange and mitochondrial-ER tethering.

bioRxiv · Sep 12, 2022Biophysics

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

Z. Vue, E. Garza-Lopez, K. Neikirk, P. Katti, L. Vang, H. K. Beasley, J.-q. Shao, A. G. Marshall, A. Crabtree, A. C. Murphy, B. C. Jenkins, P. Prasad, C. S. Evans, B. T. Taylor, M. Mungai, , Murray

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

bioRxiv · Mar 22, 2022Biophysics

Mitochondrial Network Configuration Influences Sarcomere and Myosin Filament Structure in Striated Muscles

P. Katti, A. S. Hall, P. T. Ajayi, Y. Kim, T. B. Willingham, C. K. E. Bleck, H. Wen, B. Glancy

The paper shows mitochondrial network configuration affects sarcomere and myosin filament structure in striated muscles across species.

bioRxiv · Jan 14, 2022Cell Biology

Regulation of the Evolutionarily Conserved Muscle Myofibrillar Matrix by Cell Type Dependent and Independent Mechanisms

P. T. Ajayi, P. Katti, T. B. Willingham, Y. Sun, C. K. E. Bleck, B. Glancy

The paper shows that a myofibrillar matrix is conserved across species and regulated by both cell-type dependent and independent mechanisms in Drosophila muscles.

bioRxiv · Oct 1, 2021Cell Biology

An Evolutionarily Conserved Regulatory Pathway of Muscle Mitochondrial Network Organization

P. Katti, P. T. Ajayi, A. M. Aponte, C. K. E. Bleck, B. Glancy

The paper identifies an evolutionarily conserved pathway involving cut, salm, and H15 that regulates muscle mitochondrial network organization independently of contractile fiber-type in Drosophila.

bioRxiv · Sep 30, 2021 · PreprintCell Biology

Systematic Transmission Electron Microscopy-Based Identification and 3D Reconstruction of Cellular Degradation Machinery

K. Neikirk, Z. Vue, P. Katti, B. I. Rodriguez, S. A. Omer, J. Shao, T. A. Christensen, E. Garza Lopez, A. Marshall, C. Palavicino-Maggio, J. Ponce, A. Alghanem, L. Vang, T. Barongan, H. Beasley, , A. Hinton

This paper describes methods to identify and distinguish subcellular structures involved in macroautophagy using TEM and 3D reconstruction, with applications to quantify degradation machinery under different conditions.

bioRxiv · Sep 26, 2021Biophysics

Practices for Measuring 3D Organelle Morphology and Generating Surfaces with Amira

E. Garza Lopez, Z. Vue, P. Katti, K. Neikirk, M. Biete, J. Lam, H. Beasley, A. Marshall, T. Rodman, T. A. Christensen, J. L. Salisbury, L. Vang, M. Mungai, S. AshShareef, S. Murray, , A. Hinton

The paper introduces a standardized protocol using Amira software to quantify 3D organelle morphology from SBF-SEM data, demonstrating its application to mitochondria and ER structures.

bioRxiv · Sep 25, 2021Biophysics

A comprehensive approach for artifact-free sample preparation and assessment of mitochondrial morphology in tissue and cultured cells

A. Hinton, P. Katti, T. A. Christensen, M. Mungai, J. Shao, L. Zhang, S. Trushin, A. Alghanem, A. Jaspersen, R. E. Geroux, K. Neikirk, M. Biete, E. Garza Lopez, Z. Vue, H. Beasley, , E. D. Abel

This paper presents a method for preserving and quantitatively measuring mitochondrial morphology in tissues and cultured cells without introducing artifacts.

bioRxiv · Jun 27, 2021Cell Biology

A Universal Approach to Analyzing Transmission Electron Microscopy with ImageJ

J. Lam, P. Katti, M. Biete, M. Mungai, S. AshShareef, K. Neikirk, E. Garza Lopez, Z. Vue, T. A. Christensen, H. Beasley, T. Rodman, J. L. Salisbury, B. Glancy, R. O. Pereira, E. D. Abel, A. Hinton

This paper introduces a standardized method using ImageJ to quantify subcellular organelle morphology in TEM images, focusing on mitochondria, ER, lysosomes, and autophagosomes.

bioRxiv · May 27, 2021Biophysics