A. Crabtree

Age-related MICOS Complex Dysregulation Impairs Mitochondrial 3D Architecture and Metabolic Homeostasis in the Liver

This study investigates age-related changes in mitochondrial structure and function in the liver, identifying MICOS complex dysregulation as a contributor to metabolic and structural impairments.

The MICOS Complex Regulates Mitochondrial Structure and Oxidative Stress During Age-Dependent Structural Deficits in the Kidney

This study investigates age-related mitochondrial structural deficits in the kidney, finding that the MICOS complex is impaired, leading to increased oxidative stress and mitochondrial dysfunction.

Quantitative Assessment of Morphological Changes in Lipid Droplets and Lipid-Mito Interactions with Aging in Brown Adipose

This study quantifies age-related changes in lipid droplet morphology and mitochondria-lipid interactions in murine brown adipose tissue using 3D imaging and analysis.

Methods to Utilize Pulse Wave Velocity to Measure Alterations in Cerebral and Cardiovascular Parameters

This paper presents methods to measure impedance-based pulse wave velocity in systemic and cerebral vascular systems to study cardiovascular and cerebral parameters in Alzheimer's disease models.

Components of Isolated Skeletal Muscle Differentiated Through Antibody Validation

The paper describes a method to isolate skeletal muscle from mice, generate satellite cells for culture, and validate cell populations using immunofluorescence.

Optimizing In Situ Proximity Ligation Assays for Mitochondria, ER, or MERC Markers in Skeletal Muscle Tissue and Cells

This paper describes a protocol for using proximity ligation assays (PLA) to study protein-protein interactions in mitochondria-endoplasmic reticulum contact sites (MERCs) in mouse skeletal muscle tissue and cells.

Creating Optimal Conditions for OPA1 isoforms by Western Blot in Muscle Tissue

This paper presents an optimized western blot protocol to isolate and detect five OPA1 isoforms in muscle tissue.

Ablation of Sam50 is associated with fragmentation and alterations in metabolism in murine and human myotubes

This study shows that Sam50 deficiency in myotubes leads to mitochondrial fragmentation, altered metabolism, and impaired oxidative capacity in both mice and humans.

Defining Mitochondrial Cristae Morphology Changes Induced by Aging in Brown Adipose Tissue

This study uses 3D electron microscopy to analyze mitochondrial cristae morphology in mouse brown adipose tissue across aging, finding significant structural changes in aged tissue.

Cardiovascular Hemodynamics in Mice with Tumor Necrosis Factor Receptor - Associated Factor 2 Mediated Cytoprotection in the Heart

This study evaluates global cardiac function in mice with cardiac-restricted TRAF2 overexpression, finding diminished cardiac function despite reported tolerance to ischemic insults.

Three-Dimensional Mitochondria Reconstructions of Murine Cardiac Muscle Changes in Size Across Aging

This study uses 3D imaging to show that mitochondria in aging mouse hearts lose cristae structure and volume, similar to mutations in MICOS complex genes.

3D Reconstruction of Murine Mitochondria Exhibits Changes in Structure Across Aging Linked to the MICOS Complex

This study examines age-related changes in mitochondrial 3D structure in mouse muscle and heart tissues, linking these changes to the MICOS complex and metabolic alterations.

Contagious Antibiotic Resistance: Plasmid Transfer Among Bacterial Residents of the Zebrafish Gut

This paper investigates plasmid transfer among zebrafish gut bacteria, showing that resistance spread depends on donor-recipient species combinations and highlights rare members as potential plasmid reservoirs.