C. Loomis

MetFinder: a neural network-based tool for automated quantitation of metastatic burden in histological sections from animal models

MetFinder uses a deep neural network to automate metastasis burden quantification in histological sections from mouse models, improving throughput and resolution compared to current methods.

Tumor-intrinsic LKB1-LIF signaling axis establishes a myeloid niche to promote immune evasion and tumor growth

This study identifies a LKB1-LIF signaling axis in tumors that promotes immune evasion by reprogramming myeloid cells, and shows that inhibiting LIF signaling reduces tumor growth.

A comparative study of in vitro air-liquid interface culture models of the human airway epithelium evaluating cellular heterogeneity and gene expression at single cell resolution

This study compares gene expression and cellular heterogeneity in HAE cultures derived from BCi-NS1.1 cell lines and primary cells using scRNA-Seq, finding similar morphology and transcriptional patterns but some interferon gene differences.

A neonatal mouse model characterizes transmissibility of SARS-CoV-2 variants and reveals a role for ORF8

This study establishes a neonatal mouse model to study SARS-CoV-2 transmissibility, showing variant differences in infectious shedding and identifying ORF8's role in transmission.

MAVS signaling is required for clearance of chikungunya heart infection and prevention of chronic inflammation in vascular tissue

This study investigates CHIKV-induced heart disease using mouse models and human cells, showing MAVS signaling is critical for viral clearance and preventing chronic vascular inflammation.

Integrated Systems-Analysis of the Human and Murine Pancreatic Cancer Glycomes Reveal a Tumor Promoting Role for ST6GAL1

The paper identifies ST6GAL1 as a promoter of pancreatic cancer using integrated glycomic and transcriptomic analysis across human and mouse models, showing delayed cancer formation and reduced fibrosis in a novel ST6GAL1 knockout model.

Neuraminidase B controls neuraminidase A-dependent mucus production and evasion

This study identifies the role of neuraminidase B in mucus evasion and mucus production by Streptococcus pneumoniae through enzymatic activity and gene regulation.