E. Hernando

Screening the human miRNA interactome reveals coordinated upregulation in melanoma, adding bidirectional regulation to miRNA networks.

The paper identifies miRNAs that upregulate CD98hc and ST3GAL1/ST3GAL2 in melanoma, revealing a bidirectional regulatory mechanism in miRNA networks.

Integrated in vivo functional screens and multi-omics analyses identify alpha-2,3-sialylation as essential for melanoma maintenance

Unveiling common transcriptomic features between melanoma brain metastases and neurodegenerative diseases

The paper identifies shared transcriptomic features between melanoma brain metastases and neurodegenerative diseases, highlighting key genes and providing an open-source tool for analysis.

Meta-analysis of the melanoma miRNome identifies consensus signatures of progression and prognosis regulating metabolic plasticity and stress resistance

This study identifies miRNA signatures associated with melanoma progression and prognosis by integrating transcriptomic data and analyzing miRNA-mRNA interactions.

MetFinder: a neural network-based tool for automated quantitation of metastatic burden in histological sections from animal models

MetFinder uses a deep neural network to automate metastasis burden quantification in histological sections from mouse models, improving throughput and resolution compared to current methods.

Limited Environmental Serine Confers Sensitivity to PHGDH Inhibition in Brain Metastasis

This study shows that brain metastases rely on PHGDH-mediated serine synthesis due to limited environmental serine, making them sensitive to PHGDH inhibition.

Melanoma-secreted Amyloid Beta Supresses Neuroinflammation and Promotes Brain Metastasis

This study identifies amyloid beta as a factor secreted by melanoma cells that suppresses neuroinflammation and promotes brain metastasis.