E. P. Browne

The histone methyltransferase SETD2 regulates HIV expression and latency through a post-transcriptional mechanism.

This study shows that SETD2 inhibition reduces HIV gene expression and latency by altering viral RNA splicing, not transcription.

Machine learning approaches identify immunologic signatures of total and intact HIV DNA during long-term antiretroviral therapy.

The paper uses machine learning to analyze HIV reservoir and immunology data to identify immune signatures associated with total and intact HIV DNA levels during ART.

A novel high throughput microwell outgrowth assay for HIV infected cells

The paper introduces a high-throughput microwell outgrowth assay to quantify and characterize HIV-infected cells with high sensitivity and precision.

Automated microarray for single-cell sorting and collection of lymphocytes following HIV reactivation

This paper uses microarray technology to track and sort HIV-reactivated T-lymphocytes, revealing single-cell reactivation heterogeneity and associated gene expression patterns.

Impact of cannabis use on immune cell populations and the viral reservoir in people with HIV on suppressive antiretroviral therapy.

This study examines how cannabis use affects immune cell populations and the HIV reservoir in HIV-positive individuals on antiretroviral therapy, finding reduced T cell activation and potential reservoir size reduction in some subgroups.

A modular CRISPR screen identifies individual and combination pathways contributing to HIV-1 latency

This study uses a CRISPR screen to identify pathways involved in HIV-1 latency, finding that ING3 and AZD5582 combination activates proviruses.

Integrated single-cell multiomic analysis of HIV latency reversal reveals novel regulators of viral reactivation.

The paper uses single-cell RNA-seq and ATAC-seq to analyze HIV latency reversal, identifying GATA3 as a novel regulator and demonstrating a machine learning model's predictive accuracy.

Epigenomic characterization of latent HIV infection identifies latency regulating transcription factors.

This study identifies transcription factors regulating HIV latency through epigenomic analysis of latently infected cells.

The immune cell landscape in kidneys of lupus nephritis patients

This study uses single-cell RNA-seq to analyze immune cell subsets in lupus nephritis kidneys, identifying pro-inflammatory and resolving responses and potential therapeutic targets.

Single cell analysis of quiescent HIV infection reveals host transcriptional profiles that regulate proviral latency

This study uses single-cell methods to analyze HIV latency, finding that host transcriptional profiles correlate with proviral activity levels in infected cells.

High dimensional analyses of cells dissociated from cryopreserved synovial tissue

This paper establishes a protocol for dissociating cryopreserved synovial tissue to obtain viable cells with preserved transcriptomes and surface markers, enabling high-dimensional analysis of rheumatoid arthritis pathology.