M. R. Brown

This paper investigates TMEM16A missense mutations in cancer, finding they promote tumor growth through altered signaling, independent of chloride flux.

This study shows insulin-like peptides (ILPs) in Anopheles stephensi regulate ovarian ecdysteroid production, which is necessary for yolk deposition into oocytes.

The paper develops a cost-effective method to coat cell culture vessels with amorphous calcium phosphate to model the bone microenvironment and shows its effect on prostate cancer cell survival.

FALCON systematically analyzes 61 free fatty acids to identify lipotoxic effects and a novel mediator of lipotoxicity, CMIP, in human pancreatic beta cells.

This study identifies 4-hydroxynonenal as the ligand for GDAP1, showing its binding requires a unique -loop and that mutations affecting this loop impair 4HNE binding and contribute to CMT disease.

This study examines genome size variation in eyebrights, finding significant intraspecific variation and contrasting patterns between diploid and tetraploid species.

The paper investigates genetic divergence in tetraploid Euphrasia species on Fair Isle, showing allopolyploid origins and sub-genome divergence with species-specific genetic structure.

This study shows that IL-1β disrupts β-cell circadian clocks by impairing Bmal1 expression and alters its DNA-binding patterns, linking circadian disruption to β-cell failure in diabetes.

This study examines life history trait variation in Euphrasia species, finding trade-offs between growth and reproduction and significant phenotypic plasticity in response to host quality.