J. Liao

Commensal-pathogen dynamics structure disease outcomes during Clostridioides difficile colonization

The paper investigates why C. difficile colonization leads to varying disease outcomes by studying microbiota-humanized mice and identifying commensals that mitigate virulence.

Illuminating microbial phosphorus cycling in deep-sea cold seep sediments using protein language models

This study uses a protein language model to discover new phosphorus-cycling protein families in deep-sea cold seep sediments, revealing novel microbial processes and ecological roles.

Evidence of horizontal gene transfer and environmental selection impacting antibiotic resistance evolution in soil-dwelling Listeria

This study identifies horizontal gene transfer and environmental selection as key factors in the evolution of antibiotic resistance genes in soil-dwelling Listeria species.

RSG-YOLO: Detection of rice seed germination rate based on enhanced YOLOv8 and multi-scale attention feature fusion

This paper introduces RSG-YOLO, an enhanced YOLOv8 model for rice seed germination rate detection, achieving a 4% improvement in mAP50 over YOLOv8.

Cold seeps are hotspots of deep-sea nitrogen-loss driven by microorganisms across 21 phyla

This study identifies cold seeps as significant nitrogen-loss hotspots, revealing diverse microbial communities and active nitrogen-loss genes across multiple phyla.

Granulosa cell-layer stiffening prevents the granulosa cells from escaping the post-ovulatory follicle

The paper shows that granulosa cell-layer stiffening, driven by focal adhesion assembly and LH signaling, prevents granulosa cells from escaping the post-ovulatory follicle.

Variation in the response to antibiotics and life-history across the major Pseudomonas aeruginosa clone type (mPact) panel

The paper evaluates antibiotic resistance and life-history traits across 20 Pseudomonas aeruginosa strains to identify adaptive strategies and inform new treatment approaches.

Guanylate cyclase activity of TIR1/AFB auxin receptors mediates rapid auxin responses

The paper shows TIR1/AFB auxin receptors have both adenylate and guanylate cyclase activities, mediating transcriptional reprogramming and rapid Ca2+-dependent growth responses.

On-Demand Expansion Fluorescence and Photoacoustic Microscopy (ExFLPAM)

This paper introduces ExFLPAM, a method that expands the capabilities of expansion microscopy by enabling on-demand fluorescent labeling and non-fluorescent imaging in live cells and tissues.

A comprehensive catalog with 100 million genes and 3,000 metagenome-assembled genomes from global cold seep sediments

The paper constructs a comprehensive gene and genome catalog from cold seep sediments, revealing novel microbial species and a large fraction of uncharacterized genes.

ABI5-FLZ13 Module Transcriptionally Represses Growth-related Genes to Delay Seed Germination in Response to ABA

This study identifies FLZ13 as an ABI5-interacting protein that co-represses growth-related genes to delay seed germination in response to ABA.

Microdiversity of the Vaginal Microbiome is Associated with Preterm Birth

The paper analyzes vaginal microbiome metagenomic data to identify genetic diversity and antimicrobial resistance gene associations with preterm birth.

The nematode effector Mj-NEROSs interacts with ISP influencing plastid ROS production to suppress plant immunity

The paper identifies Mj-NEROSs, an effector from root-knot nematodes, which suppresses plant immunity by interacting with ISP in plastids to reduce ROS production.

MAM-STAT3-induced upregulation of mitochondrial Ca+2 causes immunosenescence in patients with type A mandibuloacral dysplasia

This study identifies mitochondrial Ca+2 dysregulation via MAM-STAT3 as a driver of immunosenescence in type A mandibuloacral dysplasia.

Long Noncoding RNA MALAT1 is Dynamically Regulated in Leader Cells during Collective Cancer Invasion

The paper shows MALAT1 lncRNA is dynamically regulated in leader cells during collective cancer invasion, with its expression increasing when cells become leaders and decreasing when migration stops.

Phage genome cleavage enables resuscitation from Cas13-induced bacterial dormancy

This study shows that type VI CRISPR systems and DNA-cleaving restriction modification systems work together to eliminate phage DNA and neutralize infection in Listeria seeligeri.

SUMOylation of SARS-CoV-2 Nucleocapsid protein enhances its interaction affinity and plays a critical role for its nuclear translocation

This study identifies SUMOylation sites on SARS-CoV-2 N protein and shows that SUMO modification enhances its self-interaction and nuclear translocation, critical for viral replication.

Salicin modifies osteoarthritis progression by binding on IRE1α and inhibiting IRE1α mediated endoplasmic reticulum stress

Soil collected in the Great Smoky Mountains National Park yielded a novel Listeria species, L. swaminathanii, effectively expanding the sensu stricto clade to ten species

SUMO E2/E3 Enzyme Co-Recognize Substrates and Confers High Substrates Specificity

The paper develops a high-throughput method to measure protein interaction affinity without purification, applied to SUMO E2/E3 enzymes and substrates, revealing co-recognition and affinity mechanisms.

Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation

This study shows that Rho kinase regulates neutrophil NET formation, which contributes to UVB-induced skin inflammation.

scATAC-Seq reveals epigenetic heterogeneity associated with an EMT-like process in male germline stem cells and its regulation by G9a

The paper uses scATAC-seq to identify epigenetic heterogeneity in male germline stem cells associated with an EMT-like process and shows G9a regulates this process.

Identification and Characterization of a Residual Host Cell Protein Hexosaminidase B Associated with N-glycan Degradation During the Stability Study of a Therapeutic Recombinant Monoclonal Antibody Product

The paper identifies Hexosaminidase B as a residual host cell protein causing N-glycan degradation in a monoclonal antibody under stability conditions and develops strategies to mitigate its impact.

Adjacent terrestrial landscapes impact the biogeographical pattern of soil Escherichia coli in produce fields via modifying the importance of environmental selection and dispersal

This study examines how adjacent terrestrial landscapes influence soil E. coli biogeography by altering the balance between environmental selection and dispersal.

p53 induces ARTS to promote mitochondrial apoptosis

This study identifies ARTS as a p53-responsive gene that promotes mitochondrial apoptosis by interacting with p53 and enhancing its pro-apoptotic effects.

An Experimental Validation of the Computer Fluid Dynamics of Normal Human Nasal Airflow Using a Precise 3-D Printing Model

This study validates CFD simulations of nasal airflow using a 3D-printed model, showing high agreement at lower flow rates but significant deviation at higher flow rates.

Comparative genomics reveals different population structures associated with host and geographic origin in antimicrobial-resistant Salmonella enterica

This study uses comparative genomics to analyze AMR Salmonella enterica isolates from bovine and human hosts, revealing distinct genetic profiles linked to host and geographic origin.

Sub-species niche specialization in the oral microbiome is associated with nasopharyngeal carcinoma risk

This study identifies differences in the oral microbiome between NPC patients and controls, highlighting a pair of co-excluding Granulicatella adiacens variants associated with cancer risk.

Non-shared dispersal networks with heterogeneity promote species coexistence in hierarchical competitive metacommunities

Identification of orthotropic material parameters for acute, necrotic, fibrotic and remodelling myocardial infarcts in the rat

This study identifies orthotropic material parameters for different stages of myocardial infarcts in rats using inverse finite element methods and genetic algorithms.