T. Johnson

Primary cilia in the growing limb are preferentially orientated,uncoupled from centriolar position

This study investigates cilia orientation and centriole positioning in growing limbs, finding that cilia orientation is preferentially organized and independent of centriole position or mechanical loading.

BOXR1030, an anti-GPC3 CAR with exogenous GOT2 expression, shows enhanced T cell metabolism and improved antitumor activity

This paper evaluates BOXR1030, a CAR T cell therapy co-expressing GPC3-targeted CAR and GOT2, showing enhanced T cell metabolism and improved antitumor activity in preclinical models.

Experimental infection of specific-pathogen-free domestic lambs with Mycoplasma ovipneumoniae causes asymptomatic colonization of the upper airways that is resistant to antibiotic treatment

This study infects domestic lambs with Mycoplasma ovipneumoniae and finds asymptomatic upper respiratory tract colonization resistant to antibiotics and immune clearance.

Feasibility of Integrating Canine Olfaction with Chemical and Microbial Profiling of Urine to Detect Lethal Prostate Cancer

This study tests the feasibility of using canine olfaction, VOC analysis, and microbial profiling in urine to detect lethal prostate cancer, showing 71% sensitivity and 70-76% specificity.

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

A pivotal role for Nrf2 in endothelial detachment- implications for endothelial erosion of stenotic plaques

This study shows that Nrf2 activation under elevated flow and smoking induces endothelial detachment, contributing to atherosclerotic plaque erosion and acute coronary syndromes.