Author
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
5 papers
Recent·Most cited
M. Xu, M. Pradhan, K. Gorshkov…·C. Z. Chen
This paper develops a high throughput screening assay using SARS-CoV-2 pseudotyped particles to identify inhibitors of viral entry, finding 7 active compounds effective against both pseudotyped particles and live virus.
M. R. Straus, M. Bidon, T. Tang…·S. Daniel
This study tests L-type calcium channel blockers for inhibiting SARS-CoV-2 infection in cell culture, finding that felodipine and nifedipine limit virus entry and infection with minimal toxicity.
T. Tang, J. A. Jaimes, M. K. Bidon…·G. R. Whittaker
This study investigates the role of S1/S2 cleavage in SARS-CoV-2 spike protein activation, showing its necessity for early pathway entry in Calu-3 cells and involvement of proteases beyond furin.
C. Z. Chen, M. Xu, M. Pradhan…·G. R. Whittaker
This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.
M. R. Straus, T. Tang, A. L. Lai…·G. R. Whittaker
This study shows that Ca2+ ions enhance MERS-CoV fusion and infectivity by interacting with specific residues in the spike protein's fusion peptide.