G. R. Whittaker

This study shows that the Omicron BA.1.1 variant causes less severe disease, lower viral shedding, and reduced tissue replication compared to D614G and Delta variants in a feline model.

This paper analyzes the evolutionary changes in the spike protein of a Canine Coronavirus isolate, identifying relaxed selection and amino acid substitutions associated with a shift in tropism from enteric to respiratory.

This paper identifies N-0385 as a potent inhibitor of TMPRSS2 that blocks SARS-CoV-2 variants and protects mice from infection and mortality.

This study shows coagulation factors like factor Xa and thrombin directly cleave SARS-CoV-2 spike, enhancing viral entry, and suggests anticoagulation could reduce infection.

This study investigates the role of S1/S2 cleavage in SARS-CoV-2 spike protein activation, showing its necessity for early pathway entry in Calu-3 cells and involvement of proteases beyond furin.

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

This study shows that Ca2+ ions enhance MERS-CoV fusion and infectivity by interacting with specific residues in the spike protein's fusion peptide.

This study shows SPINT2 inhibits proteases needed for activation of influenza and metapneumoviruses, reducing viral growth in cell culture.

The paper models the structure of 2019-nCoV spike protein and identifies a proteolytically-sensitive loop that distinguishes it from SARS-CoV.