Author

M. Pradhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 3 Biochemistry· 1 Cell Biology· 1 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:benchmarking· 1 Research Focus:database / resource· 1 Approach:deep learning· 1

Frequent Co-Authors

M. Shen· 5 shared M. Xu· 5 shared W. Zheng· 5 shared C. Klumpp-Thomas· 4 shared C. Z. Chen· 4 shared K. Gorshkov· 4 shared W. Zhu· 4 shared H. Guo· 3 shared

Activity by Year

2020-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersPharmacology & Toxicology

M. Shen

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Super-resolution histology of paraffin-embedded samples via photonic chip-based microscopy

L. E. Villegas-Hernandez, V. K. Dubey, H. Mao, M. Pradhan, J.-C. Tinguely, D. H. Hansen, S. Acuna, B. Zapotoczny, K. Agarwal, M. Nystad, G. Acharya, K. A. Fenton, H. E. Danielsen, B. S. Ahluwalia

This paper introduces a photonic chip-based microscopy method for super-resolution imaging of FFPE tissue sections, demonstrating improved contrast and compatibility with histological workflows.

bioRxiv · Jun 14, 2023 · PreprintPathology

Gut bacteria impact host uric acid burden and its association with atherosclerosis

K. Kasahara, R. L. Kerby, Q. Zhang, M. Pradhan, M. Mehrabian, A. J. Lusis, G. Bergstrom, F. Backhed, F. E. Rey

This study shows gut bacteria influence uric acid levels and atherosclerosis in mice and humans by catabolizing purines.

bioRxiv · Dec 12, 2022 · PreprintMicrobiology

A high throughput screening assay for inhibitors of SARS-CoV-2 pseudotyped particle entry

M. Xu, M. Pradhan, K. Gorshkov, J. D. Petersen, M. Shen, H. Guo, W. Zhu, C. Klumpp-Thomas, S. Michael, M. Itkin, Z. Itkin, M. R. Straus, J. Zimmerberg, W. Zheng, G. Whittaker, C. Z. Chen

This paper develops a high throughput screening assay using SARS-CoV-2 pseudotyped particles to identify inhibitors of viral entry, finding 7 active compounds effective against both pseudotyped particles and live virus.

bioRxiv · Oct 4, 2021Pharmacology & Toxicology

Heparan sulfate assists SARS-CoV-2 in cell entry and can be targeted by approved drugs in vitro

Q. Zhang, C. Chen, M. Swaroop, M. Xu, L. Wang, J. Lee, M. Pradhan, M. Shen, Z. Luo, Y. Xu, W. Huang, W. Zheng, Y. Ye

This study shows heparan sulfate aids SARS-CoV-2 entry and identifies drugs that inhibit this process in vitro.

bioRxiv · Jul 14, 2020Cell Biology

Identifying SARS-CoV-2 entry inhibitors through drug repurposing screens of SARS- S and MERS-S pseudotyped particles

C. Z. Chen, M. Xu, M. Pradhan, K. Gorshkov, J. Petersen, M. R. Straus, W. Zhu, P. Shinn, H. Guo, M. Shen, C. Klumpp-Thomas, S. G. Michael, J. Zimmerberg, W. Zheng, G. R. Whittaker

This paper identifies six broad-spectrum inhibitors of SARS-CoV-2 and MERS-CoV spike-mediated cell entry through drug repurposing screens using pseudotyped particles.

bioRxiv · Jul 10, 2020Pharmacology & Toxicology

Real-time sharing of drug screening data on the NCATS OpenData Portal accelerates translational research

K. R. Brimacombe, P. C. Scully, T. Zhao, R. T. Eastman, X. Hu, K. Wang, M. Backus, B. Baljinnyam, C. Z. Chen, L. Chen, Y. Cheng, D. P. Davis, K. Duerr, T. Eicher, A. Friedman, , M. D. Hall

This paper describes the NCATS OpenData Portal, a platform for real-time sharing of drug screening data that accelerates translational research by enabling immediate access to large-scale datasets.

bioRxiv · Jun 4, 2020 · PreprintBiochemistry

The SARS-CoV-2 cytopathic effect is blocked with autophagy modulators

K. Gorshkov, C. Z. Chen, R. Bostwick, L. Rasmussen, M. Xu, M. Pradhan, B. N. Tran, W. Zhu, K. Shamim, W. Huang, X. Hu, M. Shen, C. Klumpp-Thomas, Z. Itkin, P. Shinn, , W. Zheng

The paper identifies six autophagy modulators that block SARS-CoV-2 cytopathic effects in Vero-E6 cells with EC50 values between 2.0 and 13 µM.

bioRxiv · May 16, 2020Pharmacology & Toxicology