ECD of PepT1 interacts with TM1 to facilitate substrate transport
J. Shen, M. Hu, Z. Ren, X. Fan, C. Portioli, X. Yan, M. Rong, M. Zhou
The paper reports the structure of PepT1 from horse, showing the extracellular domain (ECD) interacts with TM1 and bridges N- and C-domains, with ECD deletion or mutations impairing transport activity.
bioRxiv · Mar 1, 2022Biochemistry