Author

M. Slade

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Bioengineering· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1

Frequent Co-Authors

J. H. Landmann· 2 shared J. M. Warrington· 2 shared M. E. Selli· 2 shared N. Singh· 2 shared T.-C. Chang· 2 shared Y.-S. Hsu· 2 shared A. Green· 1 shared A. Gruszczynska· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersImmunology

J. H. Landmann

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Author profile →

3 papers

Recent·Most cited

Rational protein engineering to enhance MHC-independent T cell receptors

J. Chang, J. H. Landmann, T.-C. Chang, Y. Tenzin, J. M. Warrington, M. E. Selli, J. Ritchey, Y.-S. Hsu, M. Slade, D. K. Gupta, J. F. DiPersio, N. Singh

The paper designs MHC-independent T cell receptors (miTCRs) to enhance cancer immunotherapy by improving receptor stability and function through structural modeling and iterative sequence modifications.

bioRxiv · Feb 22, 2024Immunology

MRI-Guided Focused Ultrasound Blood-Brain Barrier Opening Increases Drug Delivery and Efficacy in a Diffuse Midline Glioma Mouse Model

P. J. Martinez, G. Nault, J. Steiner, M. F. Wempe, A. Pierce, B. Brunt, M. Slade, A. Mongin, J. J. Song, K.-H. Song, N. Ellens, N. Serkova, A. Green, M. A. Borden

MRI-guided focused ultrasound with microbubbles increases panobinostat delivery and efficacy in a diffuse midline glioma mouse model, reducing tumor volume and improving survival.

bioRxiv · Apr 5, 2023Bioengineering

Costimulatory domains direct distinct fates of CAR-driven T cell dysfunction

M. E. Selli, J. H. Landmann, M. Terekhova, J. Lattin, A. Heard, Y.-S. Hsu, T.-C. Chang, J. M. Warrington, H. Ha, N. Kingston, G. Hogg, M. Slade, M. M. Berrien-Elliot, M. Foster, S. Kersting-Schadek, , N. Singh

This study identifies that chronic activation of 41BB-based CARs leads to a novel T cell dysfunction state, distinct from exhaustion, which can be mitigated by disrupting FOXO3.

bioRxiv · Jan 26, 2023 · PreprintImmunology