Comprehensive Assessment of Blood-Brain Barrier Opening and Sterile Inflammatory Response: Unraveling the Therapeutic Window
P. J. Martinez, J. J. Song, F. G. Garay, K.-H. Song, T. Mufford, J. Steiner, J. DeSisto, N. Ellens, N. J. Serkova, A. L. Green, M. A. Borden
This study examines how microbubble volume doses and ultrasound mechanical indices affect BBB opening and sterile inflammation in mice, identifying a therapeutic window to optimize safe drug delivery.
bioRxiv · Oct 23, 2023Bioengineering