M. Schaefer

Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues

This paper develops and tests ideal efficacy photoswitch ligands for TRPC4/5 channels, enabling precise spatiotemporally-controlled modulation in live tissues.

The Respiratory-Pupillary Phase Effect: Pupils size is smallest around inhalation onset and largest during exhalation

This study challenges the traditional view of pupillary changes during respiration, showing pupils are smallest at inhalation onset and largest during exhalation across multiple conditions.

Persistent biofluid small molecule alterations induced by Trypanosoma cruzi infection are not restored by antiparasitic treatment

This study identifies persistent urine metabolome alterations in T. cruzi-infected mice that are not reversed by antiparasitic treatment, suggesting urine as a potential diagnostic tool for Chagas Disease.

HUWE1 controls tristetraprolin proteasomal degradation by regulating its phosphorylation

This study identifies HUWE1 as a regulator of TTP proteasomal degradation by controlling its phosphorylation, distinct from MAPK-mediated phosphorylation.

Evidence of active oviposition avoidance to systemically applied imidacloprid in the Colorado Potato Beetle (Leptinotarsa decemlineata)

This study shows that Colorado Potato Beetle females actively avoid ovipositing on imidacloprid-treated plants, suggesting learned behavior contributes to their resistance and spread.

AGO1 regulates pericentromeric regions in mouse embryonic stem cells

This study shows that AGO1 depletion in mESCs causes redistribution of H3K9me3 and HP1 away from pericentromeres and upregulates major satellite transcripts.

SF3B1 promotes tumor malignancy through splicing-independent co-activation of HIF1α

This study shows SF3B1 promotes tumor malignancy by co-activating HIF1α through a splicing-independent mechanism, enhancing hypoxia response element binding and target gene expression.

Specific decorations of 17-hydroxygeranyllinalool diterpene glycosides solve the autotoxicity problem of chemical defense in Nicotiana attenuata

The paper identifies UGT enzymes involved in the biosynthesis of HGL-DTGs in Nicotiana attenuata and shows that glucosylation prevents autotoxicity while enhancing defense against herbivores.

Assessing the impact of grassland management on landscape multifunctionality

This paper identifies optimal grassland compositions for ecosystem services using simulation and an online tool, showing that mixed intensity landscapes can maximize multifunctionality when services trade-off.