PD-L1 Restrains the PD-1hiNrp1loTGFb+ Treg to block IL6+ Neutrophil tumor infiltration to Suppress Inflammation-driven Colorectal Cancer
K. Liu, D. B. Poschel, J. Klement, A. D. Merting, C. Lu, Y. Zhao, D. Yang, W. Xiao, H. Zhu, P. Rajeshwari, M. Toscano, K. Jones, K. Madwani, A. Barret, R. Bollag, , H. Shi
This study shows PD-L1 suppresses inflammation-driven colorectal cancer by regulating Tregs, neutrophils, and gut microbiota through the PD-L1/L. murinus/PD-1hiNrp1loTGFβ+ Treg/IL6+ neutrophils pathway.
bioRxiv · Oct 12, 2023 · PreprintImmunology