A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection
S. Ghosh, S. Roy, N. Baid, U. K. Das, S. Rakshit, P. Sanghavi, D. Hajra, S. Menon, M. Sahil, S. Shaw, R. S. Rajmani, H. Adicherla, J. Mondal, D. Chakravortty, R. Mallik, A. Banerjee
The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.
bioRxiv · Jul 18, 2023 · PreprintCell Biology