S. Menon

An Integrated Machine Learning Approach Delineates an Entropic Expansion Mechanism for the Binding of a Small Molecule to α-synuclein

This study uses machine learning to show that fasudil modulates α-synuclein's conformational states through entropic expansion, offering insights into small molecule interactions with IDPs.

Modulation of α-Synuclein Aggregation Amid Diverse Environmental Perturbation

This study computationally simulates α-Synuclein aggregation under various environmental conditions, revealing how different factors influence its phase separation and structural behavior.

A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.

FET fusion oncoproteins disrupt physiologic DNA repair and create a targetable opportunity for ATR inhibitor therapy

This study shows FET fusion oncoproteins disrupt DNA repair by inhibiting ATM signaling, making ATR inhibitors a potential therapy for FET rearranged cancers.

Small molecule modulates α-Synuclein conformation and its oligomerization via Entropy Expansion

This study shows how a small molecule modulates α-synuclein's conformation and oligomerization through an entropy expansion mechanism, potentially offering therapeutic strategies for neurodegenerative diseases.

Conformational Ensemble of Monomeric α-Synuclein in Aqueous and Crowded Environments as revealed by Markov State Model

This paper uses Markov state models to characterize metastable conformations of monomeric α-synuclein in aqueous and crowded environments, revealing aggregation-prone and aggregation-resistant states.

The ubiquitylome of developing cortical neurons

This study identifies ubiquitylated substrates of TRIM9 and TRIM67 in developing cortical neurons using ubiquitin remnant profiling.

TRIM67 Regulates Exocytic Mode and Neuronal Morphogenesis via SNAP47

The paper identifies four exocytic fusion modes in developing neurons and shows TRIM67 promotes FVF-like exocytosis by limiting SNAP47 incorporation into SNARE complexes.

Outcome of radial scar/complex sclerosing lesion associated with epithelial proliferations with atypia diagnosed on breast core biopsy - Results from a multicentric UK based study

The study evaluates the upgrade rate of radial scar/complex sclerosing lesion with atypia to malignancy on surgical excision, finding higher rates with atypical ductal hyperplasia than lobular neoplasia.

TRIM9-dependent ubiquitination of DCC constrains kinase signaling, exocytosis, and axon branching

This study shows TRIM9 ubiquitinates DCC, inhibiting FAK activation, which regulates exocytosis and axon branching in neurons.