D. Chakravortty

Unravelling the Dynamics of Bacterial-Laden Respiratory Droplets: Epidemiological Transfer from Fomites to Susceptible Host

This study investigates how respiratory droplets containing Pseudomonas aeruginosa transfer pathogens via surfaces, finding increased viability with mucin and significant transfer at high humidity.

Endoplasmic Reticulum contact sites facilitate the coordinated division of Salmonella-containing vacuole (SCV)

This study shows that Salmonella effector SteA promotes ER contact sites with SCVs to coordinate their division, ensuring single bacterium per vacuole.

Weather-related changes in the dehydration of respiratory droplets on surfaces bolster bacterial endurance

This study shows that environmental conditions, particularly humidity, significantly affect the survivability of Pseudomonas Aeruginosa in respiratory droplets on surfaces.

A Tale of Twins: The Distinct Roles of Intracellular and Extracellular Formate in Regulating Flagellar and Pathogenicity Island-1 Genes in Salmonella Typhimurium

This study investigates the role of intracellular and extracellular formate in regulating virulence genes in Salmonella Typhimurium, showing that pflB deletion affects flagellation and virulence gene expression through pH and membrane changes.

Evaporation of bacteria-laden surrogate respiratory fluid droplets: On a hydrophilic substrate versus contact-free environment confers differential bacterial infectivity

This study compares bacterial infectivity in droplet nuclei formed from evaporating respiratory fluid on a hydrophilic substrate versus in a contact-free environment.

Clustered Regularly Interspaced Short Palindromic Repeats-Cas system regulates Salmonella virulence

This study shows that the CRISPR-Cas system in Salmonella enhances virulence by regulating virulence factor expression.

Salmonella Typhimurium employ spermidine to exert protection against ROS-mediated cytotoxicity and rewires host polyamine metabolism to ameliorate its survival in macrophages

This study shows Salmonella Typhimurium uses spermidine to resist ROS stress and rewires host polyamine metabolism, enhancing survival in macrophages, and suggests DFMO as a therapeutic option.

Klebsiella Pneumoniae turns more virulent under flow stresses in capillary like microchannels

This study shows that Klebsiella pneumoniae becomes more virulent under flow stresses in microchannels, as evidenced by increased proliferation in macrophages.

SIRT1 and SIRT3 impact host mitochondrial function and host- Salmonella pH balance during infection

This study shows that SIRT1 and SIRT3 regulate mitochondrial function and pH balance in macrophages during Salmonella infection, affecting bacterial gene expression.

A host AAA-ATPase exhibits bacteriolytic activity for clearance of microbial infection

The paper shows that the host AAA-ATPase VCP/p97 has bacteriolytic activity by mechanically extracting ubiquitinated proteins from bacterial membranes, leading to microbial clearance in a mouse sepsis model.

Spermidine facilitates the adhesion and subsequent invasion of Salmonella Typhimurium into epithelial cells via the regulation of surface adhesive structures and the SPI-1

This study shows that spermidine enhances Salmonella Typhimurium adhesion and invasion into epithelial cells by regulating surface structures and SPI-1 gene expression.

Salmonella Typhimurium effector SseI regulates host peroxisomal dynamics to acquire lysosomal cholesterol for better intracellular growth

The paper shows Salmonella effector SseI recruits peroxisomes to SCVs, activates ARF-1, and facilitates cholesterol transport for bacterial growth.

Salmonella-induced SIRT1 and SIRT3 are crucial for maintaining the metabolic switch in bacteria and host for successful pathogenesis

This study shows that Salmonella modulates SIRT1 and SIRT3 to maintain its metabolism and promote pathogenesis by altering host macrophage polarization and metabolism.

Syntaxin 3-SPI 2 dependent cross-talk facilitates the division of Salmonella containing vacuole (SCV)

This study shows that Syntaxin 3 interacts with Salmonella containing vacuoles (SCVs) via SPI-2 encoded T3SS, facilitating SCV division and bacterial replication in macrophages.

PHYSIOLOGICAL CHARACTERISTICS OF BACTERIAL DROPLETS INDICATE A CATASTROPHIC CONSEQUENCE WITH AN INCREASE IN IMPACT VELOCITY

This study investigates how impact velocity affects Salmonella Typhimurium viability and virulence in bacterial droplets, finding increased phoP expression and intracellular proliferation at higher velocities.

Physics of Self-Assembly and Morpho-Topological Changes of Klebsiella Pneumoniae in Desiccating Sessile Droplets

This study examines how Klebsiella Pneumoniae self-assembles and changes morphology during droplet desiccation, revealing physical mechanisms affecting bacterial survival and pathogenesis.

Deceiving The Big Eaters: Salmonella Typhimurium SopB subverts host cell Xenophagy through the Akt-TFEB axis in macrophages

This study shows Salmonella Typhimurium uses SopB to inhibit host autophagy by disrupting phosphoinositide dynamics and the Akt-TFEB axis, aiding bacterial survival and dissemination.

Outer membrane protein A (OmpA) deficient Salmonella Typhimurium displays enhanced susceptibility towards β-lactam antibiotics: third-generation cephalosporins (ceftazidime) and carbapenems (meropenem)

This study shows that deleting OmpA in Salmonella Typhimurium increases susceptibility to β-lactam antibiotics like ceftazidime and meropenem, leading to bacterial death.

The extracellular loops of Salmonella Typhimurium outer membrane protein A (OmpA) maintain the stability of Salmonella containing vacuole (SCV) in murine macrophages and protect the bacteria from autophagy-dependent lysosomal degradation

This study shows that OmpA's extracellular loops stabilize the Salmonella containing vacuole (SCV) and prevent autophagy-mediated degradation in murine macrophages.

A novel innate pathogen sensing strategy involving ubiquitination of bacterial surface proteins

The paper identifies a novel innate pathogen sensing strategy through ubiquitination of bacterial surface proteins, revealing a conserved mechanism for pathogen detection and clearance.

GH18 family glycoside hydrolase Chitinase A of Salmonella facilitates bacterial invasion and survival by modulating host immune responses

This study investigates the role of Salmonella chitinase A in facilitating bacterial invasion and survival by modulating host immune responses.

Vapor mediation as a tool to control micro-nano scale dendritic crystallization and preferential bacterial distribution in drying respiratory droplets

This paper controls dendritic crystallization and bacterial distribution in drying respiratory droplets using vapor-mediated interactions to manipulate flow dynamics and solute transfer.

Spatiotemporal evaporating droplet dynamics on fomites enhances long term bacterial pathogenesis

This study shows that evaporation-induced bacterial patterns on fomites enhance Salmonella Typhimurium virulence through hyper-proliferation in macrophages and sustained pathogenicity in mice.

Salmonella Typhimurium outer membrane protein A (OmpA) renders protection against nitrosative stress by promoting SCV stability in murine macrophages

This study shows that Salmonella Typhimurium's OmpA protein protects against nitrosative stress by stabilizing the SCV membrane, preventing bacterial release into the macrophage cytosol.

Global transcriptional regulation by cell-free supernatant of Salmonella Typhimurium peptide transporter mutant leads to inhibition of intra-species biofilm initiation

This study identifies the anti-biofilm properties of Salmonella Typhimurium cell-free supernatant from a proline peptide transporter mutant, showing it inhibits biofilm initiation through transcriptional regulation and oxidative stress.

A simple method to determine the elimination half-life of drugs displaying noncumulative toxicity

This paper introduces TOXHL, a method to determine the elimination half-life of drugs with noncumulative toxicity using survival outcomes from three experiments.