Cancer BiologybioRxiv
CXCL8/CXCR2 signaling mediates bone marrow fibrosis and represents a therapeutic target in myelofibrosis
A. Dunbar, D. Kim, M. Lu…·R. Hoffman
This study identifies CXCL8/CXCR2 signaling as a driver of bone marrow fibrosis in myelofibrosis and shows its therapeutic potential through genetic and pharmacologic inhibition.
DOI 10.1182/blood.2022015418