N. Ho

Early induction of severe cytokine release syndrome by rapidly generated CAR T cells in a preclinical mouse model

This study shows that rapidly generated CAR T cells induce severe cytokine release syndrome in a mouse model within 24 hours.

Learning Free Energy Pathways through Reinforcement Learning of Adaptive Steered Molecular Dynamics

This paper develops a reinforcement learning framework to compute low free energy pathways between states using adaptive steered molecular dynamics and robotics planning.

A comprehensive proteomic SWATH-MS workflow for profiling blood extracellular vesicles: a new avenue for glioma tumour surveillance

This study uses SWATH-MS to comprehensively profile plasma extracellular vesicles from glioma patients, identifying potential biomarkers that reflect glioma subtype and aggressiveness.

ER stress sensor Ire1 deploys a divergent transcriptional program in response to lipid bilayer stress

The paper identifies a lipid bilayer stress sensing mechanism in the UPR transducer Ire1 and shows it activates divergent transcriptional programs in yeast and C. elegans.

A subset of UPR-induced transmembrane proteins are prematurely degraded during lipid perturbation

The paper shows that lipid perturbation causes premature degradation of some UPR-induced transmembrane proteins, including Sbh1, through an unconventional ERAD pathway.