Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis
J. Simcox, G. Geoghegan, J. A. Maschek, M. Pasquali, R. Miao, S. Lee, L. Jiang, I. Huck, A. Donato, U. Apte, N. Longo, J. Rutter, J. Cox, C. J. Villanueva
This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.
bioRxiv · Apr 28, 2017Biochemistry