Author

I. Huck

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Physiology· 2 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:metabolism & bioenergetics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

U. Apte· 4 shared A. Donato· 1 shared A. Shah· 1 shared C. J. Villanueva· 1 shared D. T. Rutkowski· 1 shared E. M. Morris· 1 shared E. R. Gansemer· 1 shared G. Geoghegan· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersPhysiology

U. Apte

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Interference with the HNF4-dependent gene regulatory network diminishes ER stress in hepatocytes

A. Shah, I. Huck, K. Duncan, E. R. Gansemer, U. Apte, M. A. Stamnes, D. T. Rutkowski

The paper identifies HNF4-dependent genes suppressed by ER stress in the liver and shows that HNF4 deletion reduces UPR activation and ER stress.

bioRxiv · Feb 9, 2023 · PreprintCell Biology

Hepatocyte-Specific Hepatocyte Nuclear Factor 4 alpha (HNF4α) Deletion Decreases Resting Energy Expenditure By Disrupting Lipid and Carbohydrate Homeostasis

I. Huck, E. M. Morris, J. P. Thyfault, U. Apte

This study shows that deleting HNF4α in hepatocytes reduces resting energy expenditure by disrupting lipid and carbohydrate homeostasis in mice.

bioRxiv · Aug 27, 2018Physiology

Hepatocyte Nuclear Factor 4 alpha (HNF4α) Activation is Essential for Termination of Liver Regeneration

I. Huck, S. Gunewardena, R. Espanol-Suner, H. Willenbring, U. Apte

This study shows that HNF4α reexpression after liver injury is critical for hepatocytes to exit the cell cycle and resume function during liver regeneration.

bioRxiv · Apr 20, 2018Physiology

Global analysis of plasma lipids identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis

J. Simcox, G. Geoghegan, J. A. Maschek, M. Pasquali, R. Miao, S. Lee, L. Jiang, I. Huck, A. Donato, U. Apte, N. Longo, J. Rutter, J. Cox, C. J. Villanueva

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.

bioRxiv · Apr 28, 2017Biochemistry