J. A. Maschek

This study shows that inhibiting the Lands cycle in skeletal muscle reduces lipid hydroperoxide levels, protecting against disuse-induced atrophy and weakness in mice.

This study shows that hepatic IRE1 protects against septic cardiac failure by maintaining lipid metabolic balance, independent of inflammation.

The paper identifies distinct roles for cardiolipin and phosphatidylethanolamine in mitochondrial-derived compartment (MDC) biogenesis, showing cardiolipin is required for MDC formation while phosphatidylethanolamine depletion triggers it during amino acid stress.

This study shows weight loss increases skeletal muscle mitochondrial energy efficiency by altering cardiolipin composition, which reduces energy expenditure and prevents weight regain.

This study identifies phosphatidylethanolamine's role in regulating mitochondrial pyruvate entry, linking it to metabolic flexibility in skeletal muscle.

This study shows mitochondrial phosphatidylethanolamine directly regulates UCP1 to control thermogenesis in brown adipose tissue.

This study identifies CFAP418's role in lipid binding and membrane processes, showing that its disruption causes lipid imbalance and mitochondrial defects in retinal degenerations.

This study identifies a sex-dependent trade-off between hepatic host defense and metabolic programs in mice, showing that BCL6 protects males from infection but increases metabolic disease risk under dietary excess.

This study shows lipid hydroperoxides contribute to sarcopenia by causing carbonyl stress, and their neutralization prevents muscle atrophy and weakness.

This study identifies S1P as the sphingolipid sensed by endothelial cells via S1PRs, revealing the S1PR/ORMDLs axis as a regulatory unit controlling sphingolipid homeostasis.

This study identifies a critical role for isoprenoids in apicoplast biogenesis in malaria parasites, showing that IPP and polyprenols are essential for apicoplast membrane fluidity and inheritance.

The paper shows that serine palmitoyltransferase (SPT) modulates intestinal stem cell homeostasis by promoting stemness through sphingolipid production and PPAR-alpha activation, linking diet to cancer risk.

The paper investigates peroxisomal dysfunction in Zellweger Spectrum Disease and shows that overexpressing ATAD1 restores mitochondrial function in patient-derived fibroblasts.

This study shows that mitochondrial fatty acid synthesis (mtFAS) regulates electron transport chain (ETC) complexes and skeletal myoblast differentiation, linking fatty acid synthesis to oxidative metabolism.

This study shows that Schistosoma mansoni infection reprograms myeloid cell metabolism in male mice, with sex-dependent effects on cholesterol and glucose metabolism.

The study identifies LPCAT3 as a key regulator of plasma membrane lipid organization and insulin sensitivity in skeletal muscle, showing its role in modulating lipid metabolism and insulin action.

The paper shows that mitochondrial phospholipids, specifically phosphatidylethanolamine (PE), regulate respiratory capacity in skeletal muscle, with PE deficiency causing respiratory failure and oxidative stress.

This study identifies liver-derived acyl-carnitines as a fuel source for brown fat thermogenesis, showing that cold exposure increases plasma acylcarnitine levels through hepatic HNF4 activation and that carnitine supplementation improves thermogenic response in aged mice.