Cell BiologybioRxiv
The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death
H. Jiang, S. Panda, X. Xue…·N. O. Gekara
This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.
DOI 10.15252/embj.2019102718