X. Xue

Neuroprotection of low dose carbon monoxide in Parkinson's disease models commensurate with the reduced risk of Parkinson's among smokers

The paper shows that low-dose carbon monoxide reduces Parkinson's disease pathology in rodent models by activating HO-1, similar to the protective effect observed in smokers.

A peptide targeting outer membrane protein A of Acinetobacter baumannii exhibits antibacterial activity by reducing bacterial pathogenicity

This paper identifies a peptide, P92, that targets AbOmpA of A. baumannii, reducing bacterial pathogenicity without inhibiting growth, showing efficacy in multiple infection models.

Resting natural killer cells promote the progress of colon cancer liver metastasis by elevating tumor-derived sSCF

The paper identifies resting NK cells that promote colon cancer liver metastasis by enhancing tumor-derived sSCF through cell-to-cell interactions.

A human pluripotent stem cell-based somitogenesis model using microfluidics

This study develops a microfluidic hPSC-based model to control biochemical and biomechanical signals during somitogenesis, revealing their roles in somite formation.

Engineered display of ganglioside-sugars on protein elicits a clonally and structurally constrained B cell response

This paper shows that displaying GM3g glycans on proteins using specific chemical linkers elicits strong, germline-encoded B cell responses that do not undergo affinity maturation.

Increased plasma lipopolysaccharide-binding protein and altered inflammatory mediators in overweight women suggest a state of subclinical endotoxemia

This study finds higher plasma lipopolysaccharide-binding protein and pro-inflammatory mediators in overweight women, suggesting subclinical endotoxemia and inflammation linked to cardiovascular risk.

An Integrated Analysis of Network Pharmacology, Molecular Docking, and Experiment Validation to Explore the Mechanism of Danbai Granules in Treating Sequelae of Pelvic Inflammatory Disease

FMRP directly interacts with R-loop and shows complex interplay with the DHX9 helicase

The paper was withdrawn due to duplicate submission and is not intended for citation.

Pathobionts from chemically disrupted gut microbiota induce insulin-dependent diabetes in mice

The paper identifies Muribaculaceae family bacteria as pathobionts that induce insulin-dependent diabetes in mice through translocation to the pancreas following gut microbiota disruption.

Sucrose rather than GA transported by AtSWEET13 and AtSWEET14 supports pollen fitness at late anther development stages

This study shows that AtSWEET13 and AtSWEET14 transport sucrose, not GA, which is critical for pollen viability and germination during late anther development.

Molecular Epidemiology and Microbiological Characteristics of Cryptococcus gattii VGII isolates from China

This study analyzes C. gattii VGII isolates from China using MLST and WGS, revealing genetic diversity and virulence differences, with no drug resistance observed.

Generation of fate patterns via intercellular forces

The paper models how mechanical forces between cells influence fate patterning in stem cell colonies, showing that substrate stiffness affects pattern width non-monotonically.

FMRP DIRECTLY INTERACTS WITH R-LOOP AND SHOWS COMPLEX INTERPLAY WITH THE DHX9 HELICASE

This study shows FMRP directly binds R-loops and inhibits DHX9 helicase activity, preventing R-loop accumulation and genome instability in FXS.

Cryptic pathogen-sugar interactions revealed by universal saturation transfer analysis

This paper introduces uSTA, an NMR method to analyze protein-ligand interactions, revealing SARS-CoV-2 spike binds sialoside sugars via the NTD and showing variants-of-concern lose this binding.

Locally restricted glucose availability in the embryonic hypocotyl determines seed germination under ABA treatment

The paper shows ABA treatment restricts glucose availability in the embryonic hypocotyl, affecting seed germination through altered sugar partitioning and metabolism.

DNMT family induced down-regulation of NDRG1 via DNA methylation and clinicopathological significance in gastric cancer

The paper investigates the relationship between NDRG1 expression, DNA methylation, and DNMT family in gastric cancer, finding DNMT1 correlates with prognosis.

Immunological and pathological outcomes of SARS-CoV-2 challenge after formalin-inactivated vaccine immunisation of ferrets and rhesus macaques

This study evaluates vaccine-enhanced disease in ferrets and rhesus macaques after formalin-inactivated SARS-CoV-2 vaccination, finding mild transient lung pathology but no significant enhancement.

Micro topographical instruction of bacterial attachment, biofilm formation and in vivo host response

The paper identifies micro topographies that reduce bacterial attachment and biofilm formation, and show promise in preventing medical device infections in a mouse model.

Binding Ability Prediction between Spike Protein and Human ACE2 Reveals the Adaptive Strategy of SARS-CoV-2 in Humans

The paper predicts the binding ability between SARS-CoV-2 spike protein and human ACE2, revealing adaptive mutations that enhance transmissibility in humans.

Genetically Encoded, Multivalent Liquid Glycan Array (LiGA)

The paper introduces LiGA, a platform for analyzing glycan-lectin interactions using DNA barcoded phage displaying glycans, enabling in vitro and in vivo binding studies.

High-throughput screens of PAM-flexible Cas9 variants for gene knock-out and transcriptional modulation

The paper compares PAM-flexible Cas9 variants (xCas9 and Cas9-NG) and wild-type Cas9 across gene knock-out, activation, and suppression using a high-throughput screen, finding that PAM flexibility reduces targeting efficiency and that Cas9-NG outperforms xCas9.

Correlation of p53 and DNA repair gene mutation patterns in human malignancies indicates different tumour suppression mechanisms of p53

The paper analyzes mutation patterns of p53 and DNA repair genes in human cancers to identify differences in p53's tumor suppression mechanisms across cancer types.

Stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to HPA axis

The paper shows that stress-induced myonectin improves glucose homeostasis by inhibiting glycemic response to epinephrine and enhancing insulin sensitivity in adipose tissues.

Response of soil microbial communities to alpine meadow degradation severity levels in the Qinghai-Tibet Plateau

This study examines how soil microbial communities change with alpine meadow degradation severity on the Qinghai-Tibet Plateau, finding shifts in bacterial and fungal phyla and associations with soil and plant properties.

The innate immune DNA sensor cGAS is a negative regulator of DNA repair hence promotes genome instability and cell death

This study identifies cGAS as a negative regulator of homologous recombination DNA repair, leading to genome instability and cell death.

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma Cells

The paper isolates and characterizes LGR5-positive cells from human colon adenomas using organoids and RNA-sequencing, identifying correlations with CRC-specific genes.